Trends of antimicrobial resistance in Escherichia coli isolates from urine cultures of women in Jordan: A 10-year retrospective study

Abstract

Background: Urinary tract infection (UTI) is a common medical condition among women. E. coli is the most common causative organism. Appropriate understanding of the development of antimicrobial resistance over the past helps to establish efficient treatment strategies in the future. The study aims to determine the antimicrobial resistance trends exhibited by E. coli isolates from women urine cultures over the past 10 years. Methods: A total of 1874 positive urine samples over the years 2009 to 2018 were reviewed and classified according to the response to 24 different antimicrobial drugs in the laboratory. Relations between time and resistance evolutionary profiles were calculated. Results: Gentamicin (p value =0.039),amoxicillin(p value =0.017), cefoxitin (p value =0.001) and cefixime (p value =0.026) fulfilled satisfactory figures in terms of average resistance, regression of resistance, speed of resistance evolution, steadiness of performance, side effects, spectrum range and cost with high significance. Conclusion: Antibiotics that showed satisfactory susceptibility in culture are recommended for future treatment protocols of urinary tract infection in Jordan. Trends of antimicrobial resistance in Escherichia coli isolates from urine cultures of women in Jordan: A 10-year retrospective study Mustafa Alrabayah1, Nisreen Nadi2, Aiman Suleiman2, Ala' Abbad2, Hadil Ghanem2, Ahmad Obeidat2, Maysarah Alaqrabawi2, Mohammad Yousef2, Taima'a Harb2, Isam Bsisu2 1 Assistant professor at The University of Jordan School of Medicine/Amman. 2 Anesthesia and Intensive Care,The Jordan University Hospital/Amman, Jordan. Contact information: Dr. Nisreen Abdel-Kareem Nadi. Address: School of Medicine, The University of Jordan. PO Box 13046, Amman, 11942, Jordan.  nisreen.nadi@ymail.com