The exposure routes, organ damage and related mechanism of the microplastics on the mammal

IF 2 4区环境科学与生态学 Q3 CHEMISTRY, ANALYTICAL Environmental Chemistry Pub Date : 2021-01-01 DOI:10.7524/J.ISSN.0254-6108.2020053002

Wang Yingxue, Xu Man, W. Lixin, Cui Jiansheng

引用次数: 1

Abstract

Microplastics widely exist in the atmosphere, soil and water environment, causing extensive attention to their adverse effects on human health. We here systematically recapitulated the exposure routes of microplastics for human body and the consequent toxic effects on human organs. The exposure routes include digestive tract, respiratory tract and skin, particularly digestive tract. It has been revealed that intestinal tract, liver and kidney are the main enrichment sites of microplastics, leading to intestinal flora imbalance, intestinal function disorder and liver lipid metabolism disorder. However, the toxic effects on other tissues and systems, such as lung, kidney, nervous system and reproductive system, warrant more studies.The underlying toxic mechanisms of microplastics mainly include oxidative stress and inflammatory response. The current review would help advance the systematical understand on the health hazards of microplastics, and provide support for the risk assessment of microplastics in the future.

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微塑料对哺乳动物的暴露途径、器官损伤及相关机制

微塑料广泛存在于大气、土壤和水环境中，对人体健康的不良影响引起了广泛关注。本文系统概述了微塑料对人体的暴露途径及其对人体器官的毒性作用。暴露途径包括消化道、呼吸道和皮肤，尤其是消化道。研究表明，肠道、肝脏和肾脏是微塑料的主要富集部位，导致肠道菌群失调、肠道功能紊乱和肝脏脂质代谢紊乱。然而，对其他组织和系统的毒性作用，如肺、肾、神经系统和生殖系统，需要更多的研究。微塑料潜在的毒性机制主要包括氧化应激和炎症反应。本综述将有助于系统地认识微塑料对健康的危害，并为今后微塑料的风险评估提供支持。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Environmental Chemistry 环境科学-分析化学

CiteScore

4.50

自引率

0.00%

发文量

审稿时长

2.7 months

期刊介绍： Environmental Chemistry publishes manuscripts addressing the chemistry of the environment (air, water, earth, and biota), including the behaviour and impacts of contaminants and other anthropogenic disturbances. The scope encompasses atmospheric chemistry, geochemistry and biogeochemistry, climate change, marine and freshwater chemistry, polar chemistry, fire chemistry, soil and sediment chemistry, and chemical aspects of ecotoxicology. Papers that take an interdisciplinary approach, while advancing our understanding of the linkages between chemistry and physical or biological processes, are particularly encouraged. While focusing on the publication of important original research and timely reviews, the journal also publishes essays and opinion pieces on issues of importance to environmental scientists, such as policy and funding. Papers should be written in a style that is accessible to those outside the field, as the readership will include - in addition to chemists - biologists, toxicologists, soil scientists, and workers from government and industrial institutions. All manuscripts are rigorously peer-reviewed and professionally copy-edited. Environmental Chemistry is published with the endorsement of the Commonwealth Scientific and Industrial Research Organisation (CSIRO) and the Australian Academy of Science.