Prunus persica L., Nelumbo nucifera, Hibiscus mutabilis L., Agastache rugosa, Wolfiporia extensa Extracts to Improve Skin Wrinkles

Abstract

Purpose: In this study, mixed extracts of Prunus persica L., BATSCH, Nelumbo nucifera, Hibiscus mutabilis L., Agastache rugosa, and Wolfiporia extensa (PNHAW), which are effective in improving skin wrinkles, was prepared. The purpose of this study is to evaluate the cosmetic functionality of this extracts through a mouse animal model.Methods: In this study, skin wrinkle width evaluation, skin moisture content, erythema amount, melanin content measurement, matrix metalloproteinase-1 (MMP-1) gene expression level in skin tissue, and safety evaluation were performed to evaluate the wrinkle improvement cosmetic function of the experimental sample.Results: As a result of this study, the experimental sample PNHAW-4 showed the best efficacy. As a result of evaluating the skin wrinkle width, the experimental group showed 19.3% less than the control group, and the skin moisture content, erythema amount, and melanin content showed superior efficacy compared to the control group. In particular, the amount of erythema of PNHAW-4 (224.5) was inhibited by 43.2% compared to the control group (395.7), and melanin was decreased by 45.9% compared to the control group. In addition, PNHAW-4 inhibited the increase in MMP-1 activity by 38% compared to the control group. As a result of the experiment, the experimental sample showed an excellent skin wrinkle improvement effect.Conclusion: The results of this study suggest that the mask pack prepared from the experimental sample has an excellent collagen production promoting effect and can be applied as a safe natural wrinkle-improving cosmetic material that does not cause skin irritation.