1,5-Hydrogen atom transfer from α, β and γ carbons to an alkenyl or aryl radical in cycloalkanones

Abstract

1,5-Hydrogen atom transfer from α, β and γ carbons of cycloalkanones to an alkenyl or aryl radical on a side chain has been studied systematically. Deuterium labeling experiments and theoretical calculations were used to delineate this process. The results indicate that 1,5-hydrogen atom transfer is controlled mostly by conformational factors.