Correlation Between Pyridoxal 5’-Phospate Level And Valproic Acid In Epilepsy Children

I. Suwarba, Ni Putu Yunik Novayanti, I. Sidiartha, Dewi Sutriani Mahalini
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Abstract

Background: It is important to maintain the adequate level of vitamin B6 to ensure stable metabolism. Vitamin B6 serum level might decreased by absorption disturbance or increasing demand. Valproic acid increase the synthesis of serum GABAergic in the other hand vitamin B6 is required as cofactor for gamma-amino butyric acid (GABA) formation. The dosage and duration of valproic acid therapy might be correlated with vitamin B6 serum level. The aim of this study is to know the correlation between vitamin B6 serum level against dosage and duration of valproic acid therapy in children with epilepsy.Materials and Methods: This is a cross sectional study to investigate the correlation between vitamin B6 serum level against dosage and duration of valproic acid therapy. The level of vitamin B6 serum was determined by checking vitamin B6 active form in serum, pyridoxal 5’-phospate (PLP).Results: In this study, 37 epilepsy children with valproic acid duration therapy more than 3 months was enrolled. Fifty six percent epilepsy children were male, commonly on children age 1-5 years old. Spearman correlation coefficient test showed a significant weak negative correlation between vitamin B6 serum level and dosage of valproic acid (r=–0.35; p=0.03), and very weak negative correlation with valproic acid duration therapy (r=-0.08; p=0.59), however it was not significant. Conclusion: There was a significant weak negative correlation between vitamin B6 serum level and very weak negative correlation with valproic acid duration therapy, but not significant in children with epilepsy.Keywords: correlation, valproic acid, vitamin B6
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癫痫患儿吡哆醛5′-磷酸水平与丙戊酸的相关性研究
背景:维持足够的维生素B6水平对于保证稳定的代谢是非常重要的。维生素B6血清水平可因吸收障碍或需要量增加而降低。丙戊酸增加血清GABA能的合成,另一方面维生素B6是γ -氨基丁酸(GABA)形成的辅助因子。丙戊酸治疗的剂量和持续时间可能与血清维生素B6水平有关。本研究的目的是了解儿童癫痫患者血清维生素B6水平与丙戊酸治疗剂量和持续时间的关系。材料和方法:本研究旨在探讨维生素B6血清水平与丙戊酸治疗剂量和持续时间之间的相关性。通过检测血清中维生素B6活性形态磷酸吡哆醛(pyridoxal 5’- phosphate, PLP)测定血清中维生素B6水平。结果:本研究纳入了37例丙戊酸持续治疗3个月以上的癫痫患儿。56%的癫痫患儿为男性,通常发生在1-5岁的儿童身上。Spearman相关系数检验显示,血清维生素B6水平与丙戊酸剂量呈显著的弱负相关(r= -0.35;P =0.03),且与丙戊酸治疗时间呈极弱负相关(r=-0.08;P =0.59),但差异不显著。结论:维生素B6血清水平与丙戊酸治疗持续时间呈显著的弱负相关,与丙戊酸治疗持续时间呈极弱负相关,但在癫痫患儿中不显著。关键词:相关性,丙戊酸,维生素B6
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