Simulation and Analysis of Dynamic Biomolecule Identification Technique Based on Molecular Motors and GMR Effect

Abstract

ATP synthase is the minimal molecular motor and a highly efficient rotary machine. Giant magnetoresistance (GMR) effect is the change in electrical resistance that occurs when materials are exposed to a magnetic field. In this paper, a new dynamic biomolecule identification technique is proposed using GMR sensor combined with ATP molecular motors. Molecular motors, attached with magnetic nano-particles, can be rotated by special magnetic field. If there is specific target molecular in the sample combining with the probe molecular which is labeled on the molecular motor, the load of the molecular motor will be changed. So the movement of the molecular motor is changed, which can be detected by GMR sensor. Without the procedure of pre-treating, labeling the sample, and removing the redundant label, the biomolecule identification system could be manufactured in portable size and conveniently used in many fields. A physical model was established to simulate the identification system and a mathematic model was generated to analyze dynamics of molecular motor's rotating. The experiment results and the simulation results are consistent. It certificates the feasibility of this technique to identify biomolecule.