Stevens - Johnson Syndrome Induced by Sorafenib for Hepatocellular Carcinoma

Abstract

Dermatological examination had found: erythematous target lesion in the upper limbs and back (Figure 1), urticarial plaques on the trunk, purpuric lesions on the lower extremities and blisters stretched at the back side of 2 feet and achieving of the buccal and genital mucosa (Figure 2). Admission laboratory tests revealed several abnormal finding: hypereosinophilia in 2100 element/mm3 and hepatic cytolysis (SGOT=92 UI/L→2xN, SGPT=188 UI/L→4xN).