Pub Date : 2021-06-30DOI: 10.11648/J.IJCD.20210401.12
Ramon Hernandez Sarduy, Kevin Raul Hernandez Chinea, L. I. Pena, Maridalys Hernandez Chinea, Edilberto Pena Leyva, Marte Antonio Valdes Ibargollin
There were three cases (64, 44 and 81 years of age, all male) referred to the rehabilitation service of the Ophthalmology specialty, with the diagnosis of ophthalmic herpes zoster, due to intense pain and macular lesions, vesicles on erythematous base in the periorbital and frontal region, accompanied by intense edema. 64, 44 and 81 years old in order of appearance. Also treated, in the first instance, by dermatology with: analgesics (Dipyrone, Paracetamol), non-steroidal anti-inflammatory drugs (Ibuprofen, Piroxicam), injectable B-complex vitamin therapy, physiological therapy, eye drops and saline solutions. Pain intensity was measured by the Visual Analog Scale (VAS), at the beginning and at the end of the treatment. Acupuncture treatment for 6 to 9 sessions began on different days of the evolution of her illness. The same acupuncture treatment scheme was applied to the three patients: bilateral LI-4 (Hegu) and LI-11 (Quchi). In points on the face, the needles were placed on the healthy side: UB-2 (Zanzhu), SI-17 (Yifeng) and GB-1 (Tungtzuliao). After the first acupuncture session the pain ceased or lessened, and the blisters began to dry up. None had ocular complications and post-herpetic neuralgia did not appear after three months of finishing acupuncture therapy. The evolution was satisfactory in the 3 patients.
{"title":"Impacts of Acupuncture Therapy on Herpes Zoster: Report of 3 Cases","authors":"Ramon Hernandez Sarduy, Kevin Raul Hernandez Chinea, L. I. Pena, Maridalys Hernandez Chinea, Edilberto Pena Leyva, Marte Antonio Valdes Ibargollin","doi":"10.11648/J.IJCD.20210401.12","DOIUrl":"https://doi.org/10.11648/J.IJCD.20210401.12","url":null,"abstract":"There were three cases (64, 44 and 81 years of age, all male) referred to the rehabilitation service of the Ophthalmology specialty, with the diagnosis of ophthalmic herpes zoster, due to intense pain and macular lesions, vesicles on erythematous base in the periorbital and frontal region, accompanied by intense edema. 64, 44 and 81 years old in order of appearance. Also treated, in the first instance, by dermatology with: analgesics (Dipyrone, Paracetamol), non-steroidal anti-inflammatory drugs (Ibuprofen, Piroxicam), injectable B-complex vitamin therapy, physiological therapy, eye drops and saline solutions. Pain intensity was measured by the Visual Analog Scale (VAS), at the beginning and at the end of the treatment. Acupuncture treatment for 6 to 9 sessions began on different days of the evolution of her illness. The same acupuncture treatment scheme was applied to the three patients: bilateral LI-4 (Hegu) and LI-11 (Quchi). In points on the face, the needles were placed on the healthy side: UB-2 (Zanzhu), SI-17 (Yifeng) and GB-1 (Tungtzuliao). After the first acupuncture session the pain ceased or lessened, and the blisters began to dry up. None had ocular complications and post-herpetic neuralgia did not appear after three months of finishing acupuncture therapy. The evolution was satisfactory in the 3 patients.","PeriodicalId":15418,"journal":{"name":"Journal of Clinical Dermatology","volume":"66 1","pages":"5"},"PeriodicalIF":0.0,"publicationDate":"2021-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88762243","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-05-21DOI: 10.11648/J.IJCD.20210401.11
Jay Patel, E. Powell, S. Al-Awami, Chen Chen, Y. Huttenbach, Benjamin L. Musher, I. Orengo
Background: Leukemia cutis is an extramedullary manifestation of leukemia with infiltration of neoplastic leukocytes into the epidermis, dermis, or subcutaneous tissues. Most often it is associated with myelodysplastic syndrome or acute myelogenous leukemia. Case History: Here we present a patient with new-onset, multiple, non-tender red papules, that were initially concerning for skin metastases of her previously diagnosed pancreatic ductal adenocarcinoma. She was previously diagnosed with pancreatic cancer six years prior and was in remission until one year prior when she was found to have pulmonary metastases. The metastatic pulmonary nodules were successfully treated with radiotherapy, and the patient was in surveillance prior to presenting with a two month history of rapidly growing pink nodules on her skin. Results: Skin biopsies initially indicated this was likely not metastatic pancreatic adenocarcinoma but rather a hematologic malignancy with monocytic blast dermal infiltration. A subsequent bone-marrow biopsy and staining indicated a second primary hematologic malignancy, acute myelogenous leukemia. With the patient’s previous chemotherapy history, this new malignancy could have been treatment related. However, genetic analysis revealed this was not likely as it did not harbor known phenotypes or markers of treatment related myelodysplastic syndrome or acute myelogenous leukemia including myelomonocytic leukemia with eosinophils (FAB M4EO) or an inversion in chromosome 16 (p13q22). Instead, cytogenetics and next-generation sequencing showed trisomy 8 and a gain of function missense mutation in U2AF1. Conclusion: Maintaining a broad differential and utilizing sequential diagnostic testing confirmed a blast phase de novo acute myelogenous leukemia, presenting as leukemia cutis. She was treated with decitabine and venetoclax and within a few days of initiation, her skin nodules had already begun to recede.
{"title":"Leukemia Cutis in a Patient with Metastatic Pancreatic Cancer: A Case Report","authors":"Jay Patel, E. Powell, S. Al-Awami, Chen Chen, Y. Huttenbach, Benjamin L. Musher, I. Orengo","doi":"10.11648/J.IJCD.20210401.11","DOIUrl":"https://doi.org/10.11648/J.IJCD.20210401.11","url":null,"abstract":"Background: Leukemia cutis is an extramedullary manifestation of leukemia with infiltration of neoplastic leukocytes into the epidermis, dermis, or subcutaneous tissues. Most often it is associated with myelodysplastic syndrome or acute myelogenous leukemia. Case History: Here we present a patient with new-onset, multiple, non-tender red papules, that were initially concerning for skin metastases of her previously diagnosed pancreatic ductal adenocarcinoma. She was previously diagnosed with pancreatic cancer six years prior and was in remission until one year prior when she was found to have pulmonary metastases. The metastatic pulmonary nodules were successfully treated with radiotherapy, and the patient was in surveillance prior to presenting with a two month history of rapidly growing pink nodules on her skin. Results: Skin biopsies initially indicated this was likely not metastatic pancreatic adenocarcinoma but rather a hematologic malignancy with monocytic blast dermal infiltration. A subsequent bone-marrow biopsy and staining indicated a second primary hematologic malignancy, acute myelogenous leukemia. With the patient’s previous chemotherapy history, this new malignancy could have been treatment related. However, genetic analysis revealed this was not likely as it did not harbor known phenotypes or markers of treatment related myelodysplastic syndrome or acute myelogenous leukemia including myelomonocytic leukemia with eosinophils (FAB M4EO) or an inversion in chromosome 16 (p13q22). Instead, cytogenetics and next-generation sequencing showed trisomy 8 and a gain of function missense mutation in U2AF1. Conclusion: Maintaining a broad differential and utilizing sequential diagnostic testing confirmed a blast phase de novo acute myelogenous leukemia, presenting as leukemia cutis. She was treated with decitabine and venetoclax and within a few days of initiation, her skin nodules had already begun to recede.","PeriodicalId":15418,"journal":{"name":"Journal of Clinical Dermatology","volume":"2 1","pages":"1"},"PeriodicalIF":0.0,"publicationDate":"2021-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72682061","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-05-19DOI: 10.19070/2332-2977-2100060
Annisa Alviariza
{"title":"Dermatologic Manifestation Of COVID-19: Review Of Case Series","authors":"Annisa Alviariza","doi":"10.19070/2332-2977-2100060","DOIUrl":"https://doi.org/10.19070/2332-2977-2100060","url":null,"abstract":"","PeriodicalId":15418,"journal":{"name":"Journal of Clinical Dermatology","volume":"4 1","pages":"269-274"},"PeriodicalIF":0.0,"publicationDate":"2021-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75505368","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-03-08DOI: 10.19070/2332-2977-2100059
E. Song, Mill Creek Wa Usa. North Sound Dermatology
{"title":"Dupilumab: Friend or Foe to Alopecia Areata?","authors":"E. Song, Mill Creek Wa Usa. North Sound Dermatology","doi":"10.19070/2332-2977-2100059","DOIUrl":"https://doi.org/10.19070/2332-2977-2100059","url":null,"abstract":"","PeriodicalId":15418,"journal":{"name":"Journal of Clinical Dermatology","volume":"62 1","pages":"267-268"},"PeriodicalIF":0.0,"publicationDate":"2021-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90626040","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-12-01DOI: 10.19070/2332-2977-2000058
S. AlSogair
{"title":"A Review Of Erythroid Differentiation Regulator 1 (ERDR1) As A Therapeutic Target In Skin Inflammation","authors":"S. AlSogair","doi":"10.19070/2332-2977-2000058","DOIUrl":"https://doi.org/10.19070/2332-2977-2000058","url":null,"abstract":"","PeriodicalId":15418,"journal":{"name":"Journal of Clinical Dermatology","volume":"57 1","pages":"263-266"},"PeriodicalIF":0.0,"publicationDate":"2020-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84240511","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-11-19DOI: 10.11648/J.IJCD.20200302.13
Harshal M. Mahajan, G. Deshmukh, D. Dhoot, R. Mamadi, Hanmant Barkate
Introduction: Psoriasis is defined as chronic disease of the skin which is treated by topical drugs, systemic drugs or phototherapy depending on its severity. Vitamin D analogues are also commonly used in psoriasis, and its combination with topical corticosteroids (TCS) has shown to have synergistic action leading to more effective control of symptoms of psoriasis as well as decrement in adverse events like skin atrophy associated with prolonged TCS therapy. The present study was undertaken in pursuit of comparative assessment of effectiveness and safety of calcitriol and calcipotriol in patients diagnosed with mild psoriasis. Material and methods: This was a multicentre, retrospective data analysis and comparison between calcitriol and calcipotriol ointment done at 129 dermatology clinics across India after obtaining ethics committee approval. The data charts were identified by generating a list of all patients who were prescribed clobetasol and calcitriol as fixed dose combination for 2 weeks followed by either calcitriol (group 1) or calcipotriol (group 2) for 4 weeks at all clinics, using medical record database. Results: Out of 1076 records, a total of 630 patients met inclusion criteria. Improvement in symptoms was seen in all patients. Improvement in Physician Global assessment Score (PGAS) and Psoriasis Area and Severity Score (PASI) was seen consistently throughout the treatment period in both the groups, but greater improvement was seen in calcitriol group as compared to calcipotriol group at day 42 (p<0.05). Overall, the adverse effects in calcitriol group were less as compared to calcipotriol group. Conclusion: The findings of the present study suggests that calcitriol offers better effectiveness and safety over calcipotriol in maintenance phase of treatment of mild to moderate psoriasis and also it can serve as better option to maximise the therapeutic effect of topical corticosteroid as a fixed dose combination in acute phase of treatment.
{"title":"Comparative Clinical Assessment of Effectiveness and Safety of Calcitriol and Calcipotriol in Mild Plaque Psoriasis","authors":"Harshal M. Mahajan, G. Deshmukh, D. Dhoot, R. Mamadi, Hanmant Barkate","doi":"10.11648/J.IJCD.20200302.13","DOIUrl":"https://doi.org/10.11648/J.IJCD.20200302.13","url":null,"abstract":"Introduction: Psoriasis is defined as chronic disease of the skin which is treated by topical drugs, systemic drugs or phototherapy depending on its severity. Vitamin D analogues are also commonly used in psoriasis, and its combination with topical corticosteroids (TCS) has shown to have synergistic action leading to more effective control of symptoms of psoriasis as well as decrement in adverse events like skin atrophy associated with prolonged TCS therapy. The present study was undertaken in pursuit of comparative assessment of effectiveness and safety of calcitriol and calcipotriol in patients diagnosed with mild psoriasis. Material and methods: This was a multicentre, retrospective data analysis and comparison between calcitriol and calcipotriol ointment done at 129 dermatology clinics across India after obtaining ethics committee approval. The data charts were identified by generating a list of all patients who were prescribed clobetasol and calcitriol as fixed dose combination for 2 weeks followed by either calcitriol (group 1) or calcipotriol (group 2) for 4 weeks at all clinics, using medical record database. Results: Out of 1076 records, a total of 630 patients met inclusion criteria. Improvement in symptoms was seen in all patients. Improvement in Physician Global assessment Score (PGAS) and Psoriasis Area and Severity Score (PASI) was seen consistently throughout the treatment period in both the groups, but greater improvement was seen in calcitriol group as compared to calcipotriol group at day 42 (p<0.05). Overall, the adverse effects in calcitriol group were less as compared to calcipotriol group. Conclusion: The findings of the present study suggests that calcitriol offers better effectiveness and safety over calcipotriol in maintenance phase of treatment of mild to moderate psoriasis and also it can serve as better option to maximise the therapeutic effect of topical corticosteroid as a fixed dose combination in acute phase of treatment.","PeriodicalId":15418,"journal":{"name":"Journal of Clinical Dermatology","volume":"70 1","pages":"28"},"PeriodicalIF":0.0,"publicationDate":"2020-11-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78182887","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-11-11DOI: 10.11648/J.IJCD.20200302.12
Najat Omer Ali Alramaity, N. Elsherif, A. H. Greiw
Background: The dermatological problems in the elderly is very common, and can often add to the psychological stress in the geriatric population. Aim of the study: To determine the frequency and the patterns of skin diseases in the elderly patients. Patients and methods: A cross-sectional study was done in 100 elderly patients who attended the dermatology outpatients department in Benghazi city, from April 2018 to December 2018, females aged 50 years and above and males aged 60 years and above were evaluated for dermatological diseases. Results: Hundred elderly patients were enrolled in the study 68% were females and 32% were males. The inflammatory dermatoses were the commonest findings seen in 60% of patients, cutaneous infections seen in 36% of patients and cutaneous vascular disorders seen in 4% of patients. Eczema was the commonest inflammatory dermatosis seen in 22% of patients, pruritus was seen in 20% of patients. Seborrheic dermatitis was the commonest type of eczema seen in 9% of patients. The various types of cutaneous infections, fungal infections were seen in 15% of patients, bacterial infections seen in 14% of patients and viral infections seen in 7% of patients. Tinea pedis was the commonest seen in 10% of patients. Fungal infections were more common in female patients. Conclusions: Structural and physiological changes in aged skin can produce marked susceptibility to dermatological disorders. The inflammatory dermatosis was the most prevalent skin diseases in the elderly patients, and eczema were the predominant inflammatory dermatosis.
{"title":"A Study of Dermatological Diseases in a Geriatric Patients","authors":"Najat Omer Ali Alramaity, N. Elsherif, A. H. Greiw","doi":"10.11648/J.IJCD.20200302.12","DOIUrl":"https://doi.org/10.11648/J.IJCD.20200302.12","url":null,"abstract":"Background: The dermatological problems in the elderly is very common, and can often add to the psychological stress in the geriatric population. Aim of the study: To determine the frequency and the patterns of skin diseases in the elderly patients. Patients and methods: A cross-sectional study was done in 100 elderly patients who attended the dermatology outpatients department in Benghazi city, from April 2018 to December 2018, females aged 50 years and above and males aged 60 years and above were evaluated for dermatological diseases. Results: Hundred elderly patients were enrolled in the study 68% were females and 32% were males. The inflammatory dermatoses were the commonest findings seen in 60% of patients, cutaneous infections seen in 36% of patients and cutaneous vascular disorders seen in 4% of patients. Eczema was the commonest inflammatory dermatosis seen in 22% of patients, pruritus was seen in 20% of patients. Seborrheic dermatitis was the commonest type of eczema seen in 9% of patients. The various types of cutaneous infections, fungal infections were seen in 15% of patients, bacterial infections seen in 14% of patients and viral infections seen in 7% of patients. Tinea pedis was the commonest seen in 10% of patients. Fungal infections were more common in female patients. Conclusions: Structural and physiological changes in aged skin can produce marked susceptibility to dermatological disorders. The inflammatory dermatosis was the most prevalent skin diseases in the elderly patients, and eczema were the predominant inflammatory dermatosis.","PeriodicalId":15418,"journal":{"name":"Journal of Clinical Dermatology","volume":"76 1","pages":"22"},"PeriodicalIF":0.0,"publicationDate":"2020-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76019821","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sung-Wook Lim, Soon-Wook Kwon, M. Suh, Jin-Hyouk Choi, Jeongwoo Lee, K. Park, Jung-Ran Kim, T. Jang, Jong-Im Lee, G. Ha
{"title":"A case of subcutaneous panniculitis-like T-cell lymphoma with overlapping pathological features of lupus erythematosus","authors":"Sung-Wook Lim, Soon-Wook Kwon, M. Suh, Jin-Hyouk Choi, Jeongwoo Lee, K. Park, Jung-Ran Kim, T. Jang, Jong-Im Lee, G. Ha","doi":"10.35541/cjd.20190570","DOIUrl":"https://doi.org/10.35541/cjd.20190570","url":null,"abstract":"","PeriodicalId":15418,"journal":{"name":"Journal of Clinical Dermatology","volume":"59 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89677164","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-09-17DOI: 10.11648/J.IJCD.20200302.11
N. Sherif, S. El-Dibany, A. H. Greiw
Background: Vitiligo is an autoimmune disease characterized by the destruction of melanocytes by immune mechanisms. The role of vitamin B12 and folate in melanin synthesis has been well recognized. Aim of the study: To evaluate the serum levels of vitamin B12 and folate in Libyan patients with vitiligo vulgaris. Patients and Methods: Blood samples for haemoglobin (Hb) level, mean corpuscular volume (MCV), serum levels of Vitamin B12 and folate were obtained from 50 patients with vitiligo vulgaris and 50 age and sex-matched healthy controls at Dermatology Department of Eljumhoria Hospital in Benghazi, Libya. Results: 50 patients with vitiligo vulgaris, with mean of age 34±6 years, 34% had active disease. Blood Hb level was non-significantly lower in 26% vitiligo patients as compared to 16% control subjects (P=0.064). A significant difference was observed regarding the MCV level which was lower in vitiligo patients in comparison to that of control subjects (P=0.03). 38% of vitiligo patients have microcytic anemia (P=0.142). None of the patients has macrocytic anemia. Female patients were found to have significantly lower Hb and lower MCV than males (P=.000). Serum vitamin B12 and folate were lower in patients than control subjects and this difference was statistically significant (P=.05, P=0.001). There was no significant correlation between serum levels of vitamin B12 and folate with sex, age, family history, duration and activity of the disease ( P >0.05). Conclusions: Decreased levels of serum vitamin B12 and folate are significantly prevalent in vitiligo patients, and screening vitiligo patients for vitamin B12 and folate deficiency may be warranted.
背景:白癜风是一种以免疫机制破坏黑素细胞为特征的自身免疫性疾病。维生素B12和叶酸在黑色素合成中的作用已得到充分认识。目的:评价利比亚寻常性白癜风患者血清中维生素B12和叶酸水平。患者和方法:从利比亚班加西Eljumhoria医院皮肤科的50例寻常性白癜风患者和50例年龄和性别匹配的健康对照者中采集了血红蛋白(Hb)水平、平均红细胞体积(MCV)、血清维生素B12和叶酸水平的血液样本。结果:50例寻常性白癜风患者，平均年龄34±6岁，有活动性疾病的占34%。26%的白癜风患者血Hb水平与16%的对照组相比无显著性降低(P=0.064)。白癜风患者MCV水平较对照组低，差异有统计学意义(P=0.03)。38%的白癜风患者有小细胞性贫血(P=0.142)。所有患者均无大细胞性贫血。女性患者的Hb和MCV明显低于男性(P= 0.000)。患者血清维生素B12和叶酸水平低于对照组，差异有统计学意义(P=。05, P = 0.001)。血清维生素B12、叶酸水平与性别、年龄、家族史、病程、疾病活动度无显著相关性(P >0.05)。结论:血清维生素B12和叶酸水平降低在白癜风患者中非常普遍，对白癜风患者进行维生素B12和叶酸缺乏筛查可能是有必要的。
{"title":"Serum Vitamin B12 and Folic Acid in Vitiligo Patients: A Case Control Study","authors":"N. Sherif, S. El-Dibany, A. H. Greiw","doi":"10.11648/J.IJCD.20200302.11","DOIUrl":"https://doi.org/10.11648/J.IJCD.20200302.11","url":null,"abstract":"Background: Vitiligo is an autoimmune disease characterized by the destruction of melanocytes by immune mechanisms. The role of vitamin B12 and folate in melanin synthesis has been well recognized. Aim of the study: To evaluate the serum levels of vitamin B12 and folate in Libyan patients with vitiligo vulgaris. Patients and Methods: Blood samples for haemoglobin (Hb) level, mean corpuscular volume (MCV), serum levels of Vitamin B12 and folate were obtained from 50 patients with vitiligo vulgaris and 50 age and sex-matched healthy controls at Dermatology Department of Eljumhoria Hospital in Benghazi, Libya. Results: 50 patients with vitiligo vulgaris, with mean of age 34±6 years, 34% had active disease. Blood Hb level was non-significantly lower in 26% vitiligo patients as compared to 16% control subjects (P=0.064). A significant difference was observed regarding the MCV level which was lower in vitiligo patients in comparison to that of control subjects (P=0.03). 38% of vitiligo patients have microcytic anemia (P=0.142). None of the patients has macrocytic anemia. Female patients were found to have significantly lower Hb and lower MCV than males (P=.000). Serum vitamin B12 and folate were lower in patients than control subjects and this difference was statistically significant (P=.05, P=0.001). There was no significant correlation between serum levels of vitamin B12 and folate with sex, age, family history, duration and activity of the disease ( P >0.05). Conclusions: Decreased levels of serum vitamin B12 and folate are significantly prevalent in vitiligo patients, and screening vitiligo patients for vitamin B12 and folate deficiency may be warranted.","PeriodicalId":15418,"journal":{"name":"Journal of Clinical Dermatology","volume":"53 1","pages":"19"},"PeriodicalIF":0.0,"publicationDate":"2020-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90605467","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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