Husnain Fathima, Mohammed Yakhoob, Mohamed Khaleel
{"title":"Estimation and Validation of Abrocitinib Dosage Form and in Bulk Drug by Spectrophotometric Method","authors":"Husnain Fathima, Mohammed Yakhoob, Mohamed Khaleel","doi":"10.52711/0974-4150.2023.00037","DOIUrl":null,"url":null,"abstract":"A simple, sensitive, accurate, rapid and economical Spectrophotometric method was developed for estimation and validation of Abrocitinib in pure drug and tablet dosage form. The absorbance was measured at 303.0nm using Dimethylsulfoxideas solvent system. It obeyed Beer’s law at the concentration range of 2-14µg/ml with coefficient of correlation (r2) of 0.998. Limit of detection (LOD) was found to be 1.226µg/ml and Limit of quantitation (LOQ) was found to be 5.226µg/ml. The proposed analytical method was validated according to ICH guidelines, yielded good results concerning range, linearity, precision, accuracy, robustness and ruggedness.","PeriodicalId":8550,"journal":{"name":"Asian Journal of Research in Chemistry","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2023-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Asian Journal of Research in Chemistry","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.52711/0974-4150.2023.00037","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
A simple, sensitive, accurate, rapid and economical Spectrophotometric method was developed for estimation and validation of Abrocitinib in pure drug and tablet dosage form. The absorbance was measured at 303.0nm using Dimethylsulfoxideas solvent system. It obeyed Beer’s law at the concentration range of 2-14µg/ml with coefficient of correlation (r2) of 0.998. Limit of detection (LOD) was found to be 1.226µg/ml and Limit of quantitation (LOQ) was found to be 5.226µg/ml. The proposed analytical method was validated according to ICH guidelines, yielded good results concerning range, linearity, precision, accuracy, robustness and ruggedness.
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