José Manuel Lozano Sánchez, H. G. Morales, Paola Berenice Merch, Álvarez, JoseAlfonso Gutierrez Frusch, Ricardo Mera Mejía, Luis Felipe Montaño Estrada, Erika Patricia Rendón Huerta, Z. Serrano
{"title":"The obesity impact on fertility","authors":"José Manuel Lozano Sánchez, H. G. Morales, Paola Berenice Merch, Álvarez, JoseAlfonso Gutierrez Frusch, Ricardo Mera Mejía, Luis Felipe Montaño Estrada, Erika Patricia Rendón Huerta, Z. Serrano","doi":"10.15406/JDMDC.2018.05.00146","DOIUrl":null,"url":null,"abstract":"New studies describe that the microenvironment in uterus defines the obesity of the future new born1 affecting in a higher proportion males.2 Animal models, 3,4 have demonstrated the expression and suppression of genes associated to the mother’s diet that affect the placental microenvironment5 and promotes obesity. These state correlates with chronic low-grade inflammation6,7 and immune system activation accompanied by insulin resistance.8 On the long run, there is a long (intra uterus-pre-puberty-puberty-post puberty),9 proinflammatory environment on germ cells. Childhood and puberty","PeriodicalId":92240,"journal":{"name":"Journal of diabetes, metabolic disorders & control","volume":"1 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2018-06-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"2","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of diabetes, metabolic disorders & control","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.15406/JDMDC.2018.05.00146","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 2
Abstract
New studies describe that the microenvironment in uterus defines the obesity of the future new born1 affecting in a higher proportion males.2 Animal models, 3,4 have demonstrated the expression and suppression of genes associated to the mother’s diet that affect the placental microenvironment5 and promotes obesity. These state correlates with chronic low-grade inflammation6,7 and immune system activation accompanied by insulin resistance.8 On the long run, there is a long (intra uterus-pre-puberty-puberty-post puberty),9 proinflammatory environment on germ cells. Childhood and puberty
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