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COVID-19 with pulmonary tuberculosis with unilateral hydropneumothorax: case report from a primary care center in Bangladesh COVID-19合并肺结核并单侧气胸积液:来自孟加拉国一家初级保健中心的病例报告
Pub Date : 2021-10-05 DOI: 10.15406/jdmdc.2021.08.00227
C. Podder, N. Chowdhury
Coronavirus disease 2019 (COVID-19), the latest global pandemic has already presented with a diverse range of complications. Hydropneumothorax has been a rarer one and has been observed without preexisting lung disease and mechanical ventilation. On the other hand, Pulmonary Tuberculosis is a well-established cause of hydropneumothorax. Historically, corona viral illness had been observed to be complicated with pneumothorax and coinfection with tuberculosis .This case report enumerates concurrent tuberculosis and COVID-19 and their common grave consequence hydropneumothorax.
2019冠状病毒病(COVID-19)是最新的全球大流行,已经出现了各种各样的并发症。气胸是一种罕见的,并且没有预先存在的肺部疾病和机械通气。另一方面,肺结核是气胸积液的一个公认的原因。历史上曾观察到冠状病毒病合并气胸和合并感染结核,本文列举了合并结核和COVID-19及其常见的严重后果气胸。
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引用次数: 0
Impact of different exercise training on mitochondrial in diabetic nephropathy 不同运动训练对糖尿病肾病线粒体的影响
Pub Date : 2021-09-29 DOI: 10.15406/jdmdc.2021.08.00226
Luciana Jorge, N. Reinecke, Wesley Henrique Da Silva, Maria Lúcia SG Jorge, N. Schor
The purpose of this study was to compare the effects of aerobic, resistance and combined exercise training on mitochondrial dysfunction in diabetic nephropathy in rats. Male Wistar rats were divided into eight groups: non-diabetics (untrained, trained aerobic, trained resistance, trained combined), diabetic (untrained, trained aerobic, trained resistance, trained combined). Serum glucose levels, maximum effort test, renal function and mitochondrial biogenesis were assessed. Western blot and immunohistochemistry were used to evaluate the expression of the mitochondrial biogenesis protein and Acetil-CoA carboxylase. No differences were observed in body weight and glycaemia between diabetic rats. Diabetic animals and controls in the trained aerobic and combined groups exhibited an increase in running time, whereas animals in the trained resistance and combined groups showed greater strength. Our data suggest that exercise training can modulate the molecular pathways involved in mitochondrial biogenesis and control of renal system, decreasing the progression of diabetic nephropathy and indicating that renal disease can be prevented with non- pharmacological treatments. In conclusion, the three training protocols led to an increase in physical capacity and mitochondrial and renal benefits that were not dependent on improvements in glycemic control. In this model, combined training seems to promote more benefits than resistance or aerobic training alone.
本研究的目的是比较有氧、阻力和联合运动训练对糖尿病肾病大鼠线粒体功能障碍的影响。雄性Wistar大鼠分为8组:非糖尿病(未经训练,有氧训练,阻力训练,联合训练),糖尿病(未经训练,有氧训练,阻力训练,联合训练)。评估血清葡萄糖水平、最大努力试验、肾功能和线粒体生物发生。Western blot和免疫组化检测线粒体生物发生蛋白和乙酰辅酶a羧化酶的表达。糖尿病大鼠的体重和血糖均无差异。有氧训练组和联合训练组的糖尿病动物和对照组的跑步时间增加,而阻力训练组和联合训练组的动物表现出更大的力量。我们的数据表明,运动训练可以调节参与线粒体生物发生和肾脏系统控制的分子途径,减少糖尿病肾病的进展,表明肾脏疾病可以通过非药物治疗来预防。总之,这三种训练方案导致了身体能力的增加以及线粒体和肾脏的益处,而这些益处并不依赖于血糖控制的改善。在这个模型中,联合训练似乎比单独的阻力训练或有氧训练更有好处。
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引用次数: 1
Integrating microvascular assessments into one clinic, in an annual one-stop approach 将微血管评估整合到一个诊所,以年度一站式的方式
Pub Date : 2021-09-28 DOI: 10.15406/jdmdc.2020.07.00208
Ghassan Aldekhayel, Eman Sheshah, Dalal Al-Qaisi, R. Aman, Jumana Alzayer, Faisal Alerwy, Abdulrahman Alhadhif, M. Alsuwaidan, Weam Ahmed, Ahmed Tabash, Mohammed Alshanqiti
Background: Uncontrolled diabetes can cause many microvascular complications. Thus, early detection and appropriate treatment are essential to prevent diabetes complications that may cause disability and death. The main aim of the study is to test the effectiveness of a one stop screening clinic for retinopathy, nephropathy, and neuropathy for people with diabetes. Methods : A cross-sectional observational study, the study was done during a period of 3 months from February to March 2019. We used convenience sampling to select participants who attended the screening clinic of the Diabetes Care Center at King Salman Hospital, Riyadh, Saudi Arabia. A total of 260 diabetic patients participated in the study. Results: The study included 260 participants, around 61% were female participants. The mean age of the participants was 51 years. Most of the participants were type 2 diabetic patients (93.5%). Patients’ acceptance and satisfaction rates of the one stop clinic were 100%. Non-proliferative diabetic retinopathy prevalence was 11%. Meanwhile, the prevalence of maculopathy was 1.5%. The prevalence of micro-albuminuria was 18.6% and macro-albuminuria was 1.9%. Also, the prevalence of chronic kidney disease stage 3 was 4.2% and stage 4 was 0.4%. We found that neuropathic symptoms were present in 40.7% of the participants. The prevalence of diabetic peripheral neuropathy (DNP) according to the neuropathy disability score, which is our gold standard test was 13.8% and using 10-g monofilament test was 19.5%. Meanwhile, the prevalence of DNP according to DPN-check was 40.9%, and according to Sudoscan was 73%. Conclusion: Having one clinic that combines retinopathy, nephropathy, and neuropathy screening is possible. A one stop clinic is also highly accepted, reduces clinical visits, and can detect microvascular disease.
背景:未经控制的糖尿病可引起许多微血管并发症。因此,早期发现和适当治疗对于预防可能导致残疾和死亡的糖尿病并发症至关重要。该研究的主要目的是测试一站式筛查诊所对糖尿病患者视网膜病变、肾病和神经病变的有效性。方法:横断面观察研究,研究于2019年2月至3月进行,为期3个月。我们采用方便抽样的方法,选择在沙特阿拉伯利雅得萨勒曼国王医院糖尿病护理中心筛查诊所就诊的参与者。共有260名糖尿病患者参与了这项研究。结果:该研究包括260名参与者,其中约61%是女性参与者。参与者的平均年龄为51岁。大多数参与者为2型糖尿病患者(93.5%)。患者对一站式门诊的接受率和满意率均为100%。非增殖性糖尿病视网膜病变患病率为11%。同时,黄斑病变患病率为1.5%。微量白蛋白尿患病率为18.6%,大量白蛋白尿患病率为1.9%。此外,慢性肾脏疾病3期患病率为4.2%,4期患病率为0.4%。我们发现40.7%的参与者存在神经性症状。糖尿病周围神经病变(DNP)的患病率根据神经病变残疾评分,我们的金标准试验为13.8%,使用10-g单丝试验为19.5%。同时,DPN-check的DNP患病率为40.9%,Sudoscan的DNP患病率为73%。结论:联合视网膜病变、肾病和神经病变筛查的一家诊所是可能的。一站式诊所也被高度接受,减少了临床就诊,并可以检测微血管疾病。
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引用次数: 0
Improvement in cardiovascular and renal outcomes in type 2 diabetes: effect of glycemic control, not drugs 2型糖尿病心血管和肾脏预后的改善:血糖控制的作用,而不是药物的作用
Pub Date : 2021-09-24 DOI: 10.15406/JDMDC.2021.08.00225
U. Kabadi
because of lack of administration of equivalent daily doses in drug naive subjects. Moreover, the data regarding impact of new drugs on cardiovascular and renal outcomes is overstated as these trials demonstrate no additional improvement beyond that achieved by improvement in glycemic control. Finally
因为在初次用药的受试者中缺乏等量的日剂量。此外,关于新药对心血管和肾脏预后影响的数据被夸大了,因为这些试验表明,除了改善血糖控制外,没有其他改善。最后
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引用次数: 1
Exercise and brain function in obese & overweight people - a review 肥胖和超重人群的运动和大脑功能——综述
Pub Date : 2021-09-06 DOI: 10.15406/jdmdc.2021.08.00224
S. Ghosal, Abhro Kumar Ghosal
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引用次数: 0
The importance of continuing adequate lifestyle including exercise, daily activity and low carbohydrate diet (LCD) for type 2 diabetes mellitus (T2DM) 持续适当的生活方式,包括运动、日常活动和低碳水化合物饮食对2型糖尿病的重要性
Pub Date : 2021-07-27 DOI: 10.15406/jdmdc.2021.08.00223
Yoshiaki Sakurai, H. Bando, H. Ogawa, S. Nagahiro, M. Nakanishi, Osami Watanabe
The case was 71-year-old male patient with type 2 diabetes mellitus (T2DM). He was diagnosed T2DM at the age of 61 associated with thirsty, polydipsia and fatigue. HbA1c value was 12.5% and blood glucose profile was 150-300 mg/dL. Just after starting low carbohydrate diet (LCD), his blood glucose kept under 150 mg/dL all day long. He continued good diabetic control as HbA1c 5.8-6.8% for 10 years. Some beneficial points are found: i) keeping LCD with the feeling not stressful but pleasant for observing the normal glucose level, ii) walking daily for 2 hours, iii) continuing educational activity in the walking association for DM and health care. iv) writing the diary for years every day, including exercise, meal, medicine, activities and so on, v) checking post-prandial hyperglycemia by meal tolerance test (MTT). For details of v), HbA1c was 6.5% in May 2021 and fasting glucose was 107mg/dL. Glucose values 45-min and 60-min after 3 meals showed 210-201-177mg/dL and 195-213-172mg/dL, respectively. His various continuing behaviors contributed satisfactory glycemic control. This article becomes reference in the diabetic practice and research.
患者为男性,71岁,2型糖尿病(T2DM)。他在61岁时被诊断为2型糖尿病,伴有口渴、多饮和疲劳。HbA1c值为12.5%,血糖谱为150-300 mg/dL。刚开始低碳水化合物饮食(LCD)后,他的血糖一整天都保持在150mg /dL以下。糖尿病控制良好,糖化血红蛋白为5.8-6.8%,持续10年。我们发现了一些有益的地方:1)保持LCD的感觉不是紧张而是愉快的观察正常的血糖水平,2)每天步行2小时,3)继续步行协会的糖尿病和保健教育活动。iv)坚持多年每天写日记,包括运动、饮食、用药、活动等;v)通过膳食耐量试验(MTT)检查餐后高血糖。关于v)的细节,2021年5月HbA1c为6.5%,空腹血糖为107mg/dL。3餐后45分钟和60分钟的葡萄糖值分别为210-201-177mg/dL和195-213-172mg/dL。他的各种持续行为使血糖得到了满意的控制。本文对糖尿病的临床实践和研究具有一定的参考价值。
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引用次数: 1
Relationship of leptin hormone with body mass index and waist circumference in type 2 diabetes and non-diabetes in Sudanese 苏丹2型糖尿病和非糖尿病患者瘦素激素与体重指数和腰围的关系
Pub Date : 2021-04-09 DOI: 10.15406/jdmdc.2021.08.00222
Nahla Ahmed Mohamed, Badr Eldeen Elsooni Abdelllah, Abderahman Ahmed Mohamed Ismaeel, M. A. Ibrahim, N. Adam
Abbreviations: T2DM, type 2 diabetes mellitus; WHO, world health organization; Lep, leptin; FPG, fasting plasma glucose; HbA1c, glycosylated hemoglobin; SBP, systolic blood pressure; DBP, diastolic blood pressure; WC, waist circumference; BMI, body mass index; p, probability; r, correlation coefficient; F, degree of freedom; μg, microgram; mg, milligram; M, meter; FPG, fasting plasma glucose; WAT, white adipose tissue; BAT, brown adipose tissue
缩写:T2DM, 2型糖尿病;卫生组织,世界卫生组织;地蜡,瘦素;FPG,空腹血糖;糖化血红蛋白HbA1c;收缩压,收缩压;DBP,舒张压;WC,腰围;BMI,身体质量指数;p概率;R,相关系数;F,自由度;μg,微克;毫克,毫克;米,计;FPG,空腹血糖;WAT,白色脂肪组织;BAT,棕色脂肪组织
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引用次数: 0
Diabetes telemedicine clinic implementation during the COVID-19 virus outbreak in Saudi Arabia 沙特阿拉伯2019冠状病毒病疫情期间糖尿病远程医疗诊所的实施
Pub Date : 2021-03-29 DOI: 10.15406/jdmdc.2021.08.00221
Eman Sheshah, Khalid Kelis, N. Abdulwahid, Nahla Alswaied, R. Aman, M. Alghamdi, Rabab T. Hassanien, Amira Abbas, Lamiaa Fathy, Abdulaziz Aldokhail, Abdulaziz Alzahrany, Jawaher Alokail, Dalal Al-Qaisi, Amirah M. Basha, Ghassan Aldekhayel, Amal Azizi
Background: Saudi Arabia implemented a nationwide lockdown to slow the spread of the COVID-19 after a global pandemic has been declared by the World Health Organization. Diabetes patients are one of the most vulnerable chronic illness groups to the complications of COVID-19 virus, thus the necessary to implement a tele-medicine clinic during the lockdown. Methods: A cross-sectional observational study, the study was done during the period from October to December 2020. We used convenience sampling to select participants who attended the clinics of the Diabetes Care Center at King Salman Hospital, Riyadh, Saudi Arabia. A total of 375 patients participated in the study. Results: The study included 375 participants around 60% were female participants. The age of almost one-third of them (33.9%) ranged between 51 and 60 years. Most of the participants were type 2 diabetic patients (85.3%), and lived in Riyadh city (97.6%). Vast majority of participants (99.5%) were follow-up patients and reported telemedicine visit by physicians (98.9%). Patients’ satisfaction questions showed that majority of the participants either strongly agreed or agreed with the statements that they were satisfied with the quality of the audio during the virtual visit (92%), use of telemedicine was essential in maintaining health during the COVID-19 outbreak (90.1%), the quality of the medical care provided during the virtual visit (88.3%), the clarity of the management plan discussed with the heath care practitioner during the virtual visit (87.7%), the tele-medicine visit was as good as a regular in person visit (81.5%). Also, majority of the participants recommend making diabetes tele-medicine clinic as an available option for patients with diabetes after the COVID-19 outbreak is over (81.5%). Conclusion: The COVID-19 pandemic has urged the transition from in person clinical visits to tele-medicine clinics and showed that it is feasible and effective to have the option of tele-medicine for diabetes clinics in Saudi Arabia. The majority of diabetic patients reported high levels of satisfaction with the tele-medicine clinic.
背景:在世界卫生组织宣布新冠肺炎全球大流行后,沙特阿拉伯实施了全国封锁,以减缓新冠肺炎的传播。糖尿病患者是最容易受到COVID-19病毒并发症影响的慢性疾病群体之一,因此有必要在封锁期间实施远程医疗诊所。方法:采用横断面观察研究,研究时间为2020年10月至12月。我们采用方便抽样的方法选择在沙特阿拉伯利雅得萨勒曼国王医院糖尿病护理中心就诊的参与者。共有375名患者参与了这项研究。结果:该研究包括375名参与者,其中60%是女性参与者。其中近三分之一(33.9%)的年龄在51岁至60岁之间。大多数参与者是2型糖尿病患者(85.3%),居住在利雅得市(97.6%)。绝大多数参与者(99.5%)是随访患者,并报告了医生的远程医疗访问(98.9%)。患者满意度问题显示,大多数参与者强烈同意或同意以下陈述:他们对虚拟就诊期间的音频质量感到满意(92%),在COVID-19爆发期间使用远程医疗对于维持健康至关重要(90.1%),在虚拟就诊期间提供的医疗服务质量(88.3%),在虚拟就诊期间与卫生保健从业者讨论的管理计划的清晰度(87.7%)。远程就诊与常规上门就诊的满意度相当(81.5%)。此外,大多数参与者(81.5%)建议,在新冠肺炎疫情结束后,糖尿病患者可以选择糖尿病远程医疗诊所。结论:2019冠状病毒病大流行促使人们从亲自就诊转向远程医疗诊所,并表明沙特阿拉伯糖尿病诊所提供远程医疗选择是可行和有效的。大多数糖尿病患者对远程医疗诊所的满意度很高。
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引用次数: 0
Fibrocalculous pancreatic diabetes (FCPD)presenting as regression of puberty–a rare presentation of a rare disease 纤维结石性胰腺糖尿病(FCPD)表现为青春期退行-一种罕见疾病的罕见表现
Pub Date : 2021-03-26 DOI: 10.15406/jdmdc.2021.08.00220
S. Sarkar, Nikhil Sonthalia, Sukanya Saha, Nirmalya Roy, Ankan Pathak, Kingshuk Bhattacharjee
Here we present a case of young female who presented to us with secondary amenorrhea causing regression of puberty which is quite uncommon as a presentation of FCPD which is occasionally encountered in our day to day clinical practice. The aim of this communication is to keep a high index of suspicion and to keep FCPD as a possible aetiology which can lead to regression of puberty.
在这里,我们提出了一个年轻女性的病例,她向我们提出了继发性闭经,导致青春期退化,这是相当罕见的FCPD的表现,在我们日常的临床实践中偶尔会遇到。这种交流的目的是保持高度的怀疑指数,并保持FCPD作为可能导致青春期倒退的病因。
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引用次数: 0
Diabetes and sesame: an insight about the benefits of sesame (Sesamum indicum L.) in curing diabetes 糖尿病和芝麻:关于芝麻(Sesamum indicum L.)治疗糖尿病益处的见解
Pub Date : 2021-03-23 DOI: 10.15406/jdmdc.2021.08.00219
H. Saleem, H. Sadaqat, H. Razzaq
Diabetes in present era has become global as a lot of people are suffering from it including children. The World Health Organization (WHO) has reported that 347 million people worldwide suffer from diabetes, with about 3.4 million people dying in 2004 due to consequences of high fasting blood glucose. Diabetes killed 1.6 million people in 2018, up from less than 1 million in 2000 (WHO, 2018). It is predicted that in 2030, the seventh driving reason for death comprehensively will be diabetes. Diabetes can prompt an assortment of difficulties, including cardiovascular maladies, for example, coronary illness, vascular infection, cerebrovascular sickness, and numerous sorts of visual ailment, for example, retinopathy, nephropathy, and neuropath Sesame has for some time been viewed as a valuable herb. Impacts of sesame in lessening glycemia and improving the diabetes status and its entanglements have for some time been illustrated. In any case, barely any reports propose that sesame can help in improving cardiovascular inconveniences in diabetic patients, and along these lines requires further research.
当今时代,包括儿童在内的许多人都患有糖尿病,因此糖尿病已成为全球性疾病。世界卫生组织(世卫组织)报告说,全世界有3.47亿人患有糖尿病,2004年约有340万人因空腹血糖过高而死亡。2018年,糖尿病导致160万人死亡,高于2000年的不到100万人(世卫组织,2018年)。据预测,到2030年,糖尿病将成为综合死亡的第七大驱动原因。糖尿病会引发各种各样的疾病,包括心血管疾病,例如冠状动脉疾病,血管感染,脑血管疾病,以及各种视觉疾病,例如视网膜病变,肾病和神经病变。芝麻一直被视为一种有价值的草药。芝麻在降低血糖和改善糖尿病状态及其纠缠方面的影响已经有一段时间了。无论如何,几乎没有任何报告提出芝麻可以帮助改善糖尿病患者的心血管疾病,这需要进一步的研究。
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引用次数: 4
期刊
Journal of diabetes, metabolic disorders & control
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