Analysis of drug utilization pattern of antimicrobials used as surgical prophylaxis for general surgical procedures in a Tertiary Care Hospital of North Karnataka: An observational study

Abstract

Background: Surgical site infection (SSI) is an infection presenting within 30 days after the surgical procedure if no prosthetic is placed and up to 1 year if prosthetic is implanted in the patient. Despite standard protocols for preoperative preparation and antimicrobial prophylaxis, the rate of SSI varies from 2.5% to 41.9%. Reasons could be multifactorial, but one among them is lack of adherence to any of the antibiotic policy. To review the drug utilization pattern of antimicrobials in the perioperative period and to study its impact on SSI, the above study has been carried out. Materials and Methods: A cross-sectional, observational study has been carried out in the Department of General surgery of SBM Patil Medical College Hospital. Patients of either sex who underwent surgical procedures such as appendectomy and hernioplasty have been included in the study. Data were collected using a predesigned pro forma. The study was approved by the institutional ethics committee. Results: A total of 140 patients underwent surgical procedures, of which 70 were male and 70 were female. Open appendectomy was the most common procedure performed, followed by hernioplasty in 18 patients. Ceftriaxone–sulbactam was the frequently prescribed antibiotic and six patients developed SSI. Conclusion: Despite use of antibiotics, six patients developed SSI. Hence, auditing of the antimicrobial usage as surgical prophylaxis is need of the hour. Because prescriber's worldwide running out of antibiotic options, it is mandatory for each hospital to have formulary for antibiotic use depending on the pattern of organisms isolated.