Effect of an Aqueous Extract of Fenugreek (Trigonella Foenum Graecum) seeds on Hyperglycemia Induced with Alloxan

Significances of Bioengineering & Biosciences Pub Date : 2020-12-10 DOI:10.31031/SBB.2020.04.000584

Dakah Abdulkarim, Aljabari Bayan, Al Khateeb Kindaa

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Abstract

Background: Diabetes mellitus is a metabolic disease that causes high blood sugar. The number of people suffering from the disease worldwide is increasing at an alarming rate. Fenugreek ( Trigonella foenum-graecum ) is an herb long used in alternative medicine. This herb has many health benefits. These benefits may be due to fenugreek’s role in improving insulin function. Objectives: To evaluate antidiabetic effects of Fenugreek seeds extract on Alloxan-induced diabetic mice. Methods: The total of 30 mice (n=10) were grouped randomly into 3 groups as followings: Group I: Normal control (NC), Group II: Diabetic control (DC) and Group III: Treatment Diabetic Group (DT). Mice were injected with subcutaneous injection 180mg/kg body of freshly prepared of Alloxan and Diabetes mellitus confirmed by testing blood glucose, and mice with blood glucose level of ≥200mg/dl were considered as diabetic. Diabetic mice were received 10mg/kg of body weight from fenugreek extract. Result: All Diabetic mice that received extract showed a significant decrease in blood sugar (P<0.01). Conclusion: Fenugreek seeds reduce blood sugar levels.

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胡芦巴种子水提物对四氧嘧啶诱导的高血糖的影响

背景:糖尿病是一种引起高血糖的代谢性疾病。全世界患有这种疾病的人数正在以惊人的速度增加。葫芦巴(Trigonella foenum-graecum)是长期用于替代医学的草药。这种草药对健康有很多好处。这些益处可能是由于胡芦巴在改善胰岛素功能方面的作用。目的:探讨胡芦巴籽提取物对四氧嘧啶诱导的糖尿病小鼠的抗糖尿病作用。方法:将30只小鼠(n=10)随机分为3组:ⅰ组:正常对照组(NC)，ⅱ组:糖尿病对照组(DC)，ⅲ组:治疗糖尿病组(DT)。小鼠皮下注射新鲜配制的四氧嘧啶180mg/kg体，血糖测定证实为糖尿病，血糖≥200mg/dl为糖尿病。给予糖尿病小鼠10mg/kg体重的胡芦巴提取物。结果:糖尿病小鼠血糖均明显降低(P<0.01)。结论:胡芦巴籽可降低血糖水平。

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Significances of Bioengineering & Biosciences

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