Studies on properties of Novel natural disintegrant after processing of Spray dried and Freez dried technique

Khairnar Suhas Kishor, Shadab Husain Ashfaque Husain, Patil Pooja Ravsaheb, Gangurde A.B, V. Bairagi
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Abstract

Natural disintegrant are widely used in the development of mouth dissolving tablets and other formulation because of easily available, low cost and rapide onset of action in the mouth dissolving tablet and it enhance the bioavalaibility and disintegration properties as comparaed to synthetic polymer. But aftrer freeze drying and spray drying technique the properties of dsintegrant is increases because its improve the bulkiness and flow property of a powder such as bulk density, tapped density, angle of repose, hausner raio, carrs index etc. by freeze drying the powder are dried and thereby increase the dissolution and disintegration time and highly porous powder is produced by spray drying technique.
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新型天然崩解剂喷雾干燥和冷冻干燥后的性能研究
天然崩解剂因其易获得、成本低、起效快等优点,与合成聚合物相比,具有较高的生物利用度和崩解性能,被广泛应用于口腔崩解片等制剂的研制。而经过冷冻干燥和喷雾干燥技术后,崩解剂的性能有所提高,因为它改善了粉体的体积性和流动性,如堆积密度、出丝密度、休歇角、豪斯纳比、卡尔斯指数等。通过冷冻干燥,使粉体干燥,从而延长了溶解崩解时间,从而使喷雾干燥技术生产出高多孔粉体。
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