Electrochemical Oxidation and Determination of Norepinephrine in the Presence of Ascorbic Acid and Uric Acid at a Poly(Calconcarboxylic Acid)-Modified Electrode

Abstract

A poly(calconcarboxylic acid) film was prepared originally via electrochemically depositing calconcarboxylic acid (CCA) on a glassy carbon electrode (GCE) by cyclic voltammetry (CV). The polymer showed excellent electrocatalytic activity to the oxidation of norepinephrine and could detect separately ascorbic acid (AA), norepinephrine (NE) and uric acid (UA) in their mixture. Separations of the oxidation peak potentials of NE-AA and UA-AA were 160 and 150 mV, respectively. Using differential pulse voltammetry (DPV), the peak current of NE was linearly dependent on its concentration within the range of 10–300 μmol L^-1. No interference was produced for the determination of NE in the presence of AA and UA. Owing to its good selectivity and robustness, the poly(CCA)-modified GCE was used for the determination of NE in injections with satisfactory results.