P. Korkmaz, N. Demirturk, A. Batırel, N. Tulek, M. Ozguler, R. Harman, G. Cınar, O. Toka, Gulsen Yoruk, C. Ataman-Hatipoglu, Figen Sarigul, F. Sırmatel, Ayfer İmre, Duru Mistanoğlu-Ozatag, F. Karakeçili, O. Ural, S. Sumer, Nazlım Aktug-Demir, A. Kadanalı, Ş. Çomoğlu, S. Ucer, N. Saltoğlu, Ö. Günal, H. D. Ozkaya, E. Yenilmez, R. Çetinkaya, E. Yüksel, I. Hakyemez, M. Meriç-Koç, Gunay Tuncer-Ertem, Zehra Bestepe-Dursun, I. Çelik, E. Yılmaz, Güliz Evik, A. Kaya, K. Suer, Tip Fakultesi Biyoistatistik Anabilim Dali Ankara Turk Hacettepe Universitesi
{"title":"Effect of Hepatosteatosis on the Virological Response in Entecavir and Tenofovir Therapies","authors":"P. Korkmaz, N. Demirturk, A. Batırel, N. Tulek, M. Ozguler, R. Harman, G. Cınar, O. Toka, Gulsen Yoruk, C. Ataman-Hatipoglu, Figen Sarigul, F. Sırmatel, Ayfer İmre, Duru Mistanoğlu-Ozatag, F. Karakeçili, O. Ural, S. Sumer, Nazlım Aktug-Demir, A. Kadanalı, Ş. Çomoğlu, S. Ucer, N. Saltoğlu, Ö. Günal, H. D. Ozkaya, E. Yenilmez, R. Çetinkaya, E. Yüksel, I. Hakyemez, M. Meriç-Koç, Gunay Tuncer-Ertem, Zehra Bestepe-Dursun, I. Çelik, E. Yılmaz, Güliz Evik, A. Kaya, K. Suer, Tip Fakultesi Biyoistatistik Anabilim Dali Ankara Turk Hacettepe Universitesi","doi":"10.5152/kd.2019.73","DOIUrl":null,"url":null,"abstract":"Objective: Both chronic hepatitis B (CHB) and hepatosteatosis may lead to necroinflammation in liver. Therefore, the presence of hepatosteatosis might negatively affect the efficacy of antiviral therapy. We aimed to determine the effect of hepatosteatosis on virological response in patients with CHB receiving entecavir (ETV) and tenofovir (TDF) treatment. Methods: The study was designed retrospectively. All patients receiving antiviral therapy due to CHB in the departments of Infectious Diseases and Clinical Microbiology of 29 different hospitals between January 2012 and June 2017 were searched by examining medical records. Results: A total of 1069 patients were included. Six hundred and fifty of the patients had been receiving TDF and 419 of them had been receiving ETV. The rate of virological response obtained at the 48th week of TDF was higher in patients with steatosis (p=0.029). Virological response at the 24th week and 48th week of ETV were higher in the patients without steatosis (p=0.001). TDF and ETV therapies were compared in the patients with hepatosteatosis and it was found that the virological response at 48th week was higher in the TDF group. Conclusion: Although steatosis has an effect on virological response in the short-term results of nucleos(t)ide therapy, it does not have any effect on virological response in the long-term results. Klimik Dergisi 2019; 32(3): 265-74.","PeriodicalId":17826,"journal":{"name":"Klimik Dergisi/Klimik Journal","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2020-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Klimik Dergisi/Klimik Journal","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.5152/kd.2019.73","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
Objective: Both chronic hepatitis B (CHB) and hepatosteatosis may lead to necroinflammation in liver. Therefore, the presence of hepatosteatosis might negatively affect the efficacy of antiviral therapy. We aimed to determine the effect of hepatosteatosis on virological response in patients with CHB receiving entecavir (ETV) and tenofovir (TDF) treatment. Methods: The study was designed retrospectively. All patients receiving antiviral therapy due to CHB in the departments of Infectious Diseases and Clinical Microbiology of 29 different hospitals between January 2012 and June 2017 were searched by examining medical records. Results: A total of 1069 patients were included. Six hundred and fifty of the patients had been receiving TDF and 419 of them had been receiving ETV. The rate of virological response obtained at the 48th week of TDF was higher in patients with steatosis (p=0.029). Virological response at the 24th week and 48th week of ETV were higher in the patients without steatosis (p=0.001). TDF and ETV therapies were compared in the patients with hepatosteatosis and it was found that the virological response at 48th week was higher in the TDF group. Conclusion: Although steatosis has an effect on virological response in the short-term results of nucleos(t)ide therapy, it does not have any effect on virological response in the long-term results. Klimik Dergisi 2019; 32(3): 265-74.