Mixture prepared with Chinese medicines in terms of releasing exterior cold and clearing interior heat: its efficacy and safety in patients with seasonal influenza-a randomized controlled trial

IF 2 4区 医学 Q2 INTEGRATIVE & COMPLEMENTARY MEDICINE Journal of Traditional Chinese Medicine Pub Date : 2018-10-01 DOI:10.1016/S0254-6272(18)30914-2
Wu Zhisong , Li Guodong , Wei Wan , Liu Zhaoheng , Wang Wei , Ma Ruihong , Liu Wenhong , Ma Jiaju , Wang Yuguang , Jiao Yang
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引用次数: 2

Abstract

OBJECTIVE

To assess the efficacy and safety in 105 patients with seasonal Influenza in Beijing, the mixture prepared with Chinese medicines follows the treatment regimen of releasing exterior cold and clearing interior heat.

METHODS

Total 330 patients with seasonal influenza were enrolled and randomly and averagely divided into the Chinese herbal medicine, the western medicine and the Chinese patent medicine group. They were treated with Chinese medicine Oseltamivir Phosphate Capsules and the Scattering Wind and Resolving Toxins Capsules. The main efficacy indicators were the antifebrile onset time and recovery time of body temperature. The efficacy and safety of the mixture was scientifically evaluated. Comparisons of several variables were analyzed.

RESULTS

Median antifebrile onset time of the Chinese herbal medicine group was significantly shorter than the western medicine group (P < 0.05) and the Chinese patent medicine group (P < 0.05). The median antifebrile recovery time of the Chinese herbal medicine group was significantly shorter than the Chinese patent medicine group (P < 0.05). The groups evaluated by TCM symptom pattern effect, both the Chinese herbal medicine group and Western Medicine group were better than the Chinese patent medicine group (P < 0.05). The disappearance rate of main symptoms and some minor symptom patterns of the Chinese herbal medicine group were higher than the other 2 groups.

CONCLUSION

The mixture of releasing exterior cold and clearing interior heat could significantly shorten the fever time with safety.

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中药复方外冷清热对季节性流感患者的疗效及安全性——随机对照试验
目的观察中药配伍治疗北京地区105例季节性流感患者的疗效和安全性,治疗方案为外寒清热。方法将330例季节性流感患者随机平均分为中草药组、西药组和中成药组。采用中药磷酸奥司他韦胶囊和散风解毒胶囊治疗。主要疗效指标为退热起效时间和体温恢复时间。科学评价了合剂的有效性和安全性。对几个变量进行了比较分析。结果中草药组抗热起效时间中位数显著短于西药组(P <0.05),中成药组(P <0.05)。中草药组的中位解热恢复时间显著短于中成药组(P <0.05)。以中医证型疗效评价各组,中草药组和西药组均优于中成药组(P <0.05)。中草药治疗组的主要症状及部分次要症状消失率均高于其他两组。结论外冷清热混合使用能明显缩短发热时间,且安全。
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来源期刊
Journal of Traditional Chinese Medicine
Journal of Traditional Chinese Medicine INTEGRATIVE & COMPLEMENTARY MEDICINE-
CiteScore
2.40
自引率
3.80%
发文量
32269
审稿时长
2 months
期刊介绍: Journal of Traditional Chinese Medicine(JTCM) is devoted to clinical and theortical research on the use of acupuncture and Oriental medicine. The main columns include Clinical Observations, Basic Investigations, Reviews, Questions and Answers, an Expert''s Forum, and Discussions of Clinical Cases. Its key topics include acupuncture and electro-acupuncture, herbal medicine, homeopathy, masseotherapy, mind-body therapies, palliative care, and other CAM therapies.
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