TRACE ELEMENTS IN THE BLOOD COAGULATION SYSTEM IN ISCHEMIC STROKE: A CLINICAL STUDY

Abstract

The basis of the mechanism of ischemic brain tissue are hematological disorders. It is known that divalent ions influence the formation and structure of fibrin. In connection with this fact, a change in macro- and microelement balance serves as a marker of neurotrophic disturbances in the brain long before their clinical manifestations. The imbalance of metal-ligand homeostasis is an unfavorable background for the debut of ischemic stroke. In a multifactorial coagulation system, specific proteins - Protein C and D-dimers - occupy a key place. Many macro- and microelements are mediators of homeostasis and thrombosis: violations of elemental homeostasis are the molecular basis of the ischemic process. In a study conducted in a clinical setting, the combined dynamics of protein C and D-dimers and a complex of macro- and microelements are shown with a high degree of certainty. Using Spearman correlation analysis, reliable correlations were revealed between the concentrations of protein C, D-dimers and macro- and microelements in patients diagnosed with ischemic insult. In the final part of the mathematical processing of the results, multiple regression analysis was used, with the help of which a reliable relationship between protein C, a component of the blood coagulation system, and the concentration of a complex of macro- and microelements contributing to the central mechanism of etiopathogenesis of ischemic stroke is shown: R = 0.95938848, R2 = 0.92042626.