Protective influence of the zinc complex of 1-butylvioluric acid on the development of the liver tissue culture in the presence of convulsive poisons

T. A. Kolbasova, N. Chalisova, E. S. Egozova, Polina Nikolaevna Ivanova, K. Krasnov, Aleksandr Yakovlevich Bespalov
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Abstract

Introduction. Currently, the actual problem is the search for substances that can be used as drugs for the pharmacological correction of the effects of cytostatic damage by convulsive poisons. It is known that the liver is the first organ to encounter any foreign molecule carried by the portal bloodstream, and it is the most damaged. The aim of this work was to study the effect of the zinc complex of 1-butylvioluric acid on the development of an organotypic culture of rat liver tissue after poisoning with 2-(dimethylaminomethyl)phenyl ester of dimethylcarbamic acid hydrochloride. Material and methods. White 3-month-old male Wistar rats were used in the experiment. To study the effects of the test substances, liver tissue was selected and the method of organotypic cultivation was applied. Poisoning with convulsive poisons was modeled using 2-(dimethylaminomethyl)phenyl ester of dimethylcarbamic acid hydrochloride and the zinc complex of 1-butylvioluric acid was used as a drug for pharmacological correction of the effects of liver tissue damage. Results. The data obtained indicate that under the action of 2-(dimethylaminomethyl) phenyl ester of dimethylcarbamic acid hydrochloride, which simulates the effect of convulsive poisons on liver cells, their cell proliferation is inhibited. It was also found that the zinc complex of 1-butylvioluric acid eliminates the inhibitory effect of 2-(dimethylaminomethyl)phenyl ester of dimethylcarbamic acid hydrochloride on the proliferation of liver tissue culture. Research limitations. The study was performed on a culture of rat liver cells; to extrapolate data to the whole organism, it is necessary to take into account the data of toxicodynamics and toxicokinetics. Conclusion. Thus, the data obtained in the experiments prove the effectiveness of the use of the zinc complex of 1-butylvioluric acid as a drug for the pharmacological correction of the consequences of exposure to convulsive poisons, and also create a basis for its further study.
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1-丁基紫尿酸锌络合物对惊厥中毒肝组织培养发育的保护作用
介绍。目前,实际的问题是寻找可以用作药物的物质,以药理学上纠正抽搐毒物造成的细胞抑制损伤的影响。众所周知,肝脏是第一个遇到门静脉血流携带的外来分子的器官,也是受损最严重的。本研究旨在研究1-丁基紫尿酸锌配合物对2-(二甲氨基甲基)苯基酯中毒大鼠肝组织器官型培养的影响。材料和方法。实验选用3个月大的雄性Wistar大鼠。为研究试验物质对肝组织的影响,采用器官型培养方法。以2-(二甲氨基甲基)苯基酯二甲氨基甲酸盐酸盐为模型,以1-丁基紫尿酸锌配合物作为药物对肝组织损伤的药理矫正作用。结果。结果表明,模拟惊厥毒物作用于肝细胞的2-(二甲氨基甲基)苯基酯在其作用下,抑制肝细胞增殖。还发现1-丁基紫尿酸锌配合物消除了2-(二甲氨基甲基)盐酸二甲氨基甲酸苯酯对肝组织培养增殖的抑制作用。研究的局限性。该研究是在大鼠肝细胞培养上进行的;为了将数据外推到整个生物体,有必要考虑到毒物动力学和毒物动力学的数据。结论。因此,本实验所获得的数据证明了1-丁基紫尿酸锌配合物作为药物对惊厥中毒暴露后果的药理学矫正的有效性,也为其进一步的研究奠定了基础。
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