Vulvar Lesion Mimicking Vitiligo Revealing a Squamous Cell Carcinoma

Abstract

Melanocytes respond to trauma or cutaneous inflammation by producing varying amounts of melanin, which manifests as either hyperpigmentation or hypopigmentation. Post inflammatory Hypopigmentation (PIH) is an acquired partial or total loss of skin pigmentation that occurs after cutaneous inflammation or injury [1]. Mechanisms and pathogenesis of PIH remain unclear. It is difficult to understand how individuals respond to inflammation differently. Skin discoloration is the primary clinical indication of pigment incontinence [2]. Vitiligo, another disease that presents similarly, is often confused with PIH. Significant contrast in wood light and dermoscopy can lead to a positive diagnosis of vitiligo.