Antifungal potential of purified 3-(4-isopropylstyryl)-5-methylcyclohex-2-enone from marine actinobacteria Streptomyces albus A18

Abstract

Actinomycetes are known to produce potential secondary metabolites which comprise biological activity. The present work endeavor is to assess the fungicidal property of novel marine actinobacterial compound 3-(4-isopropylstyryl)-5-methylcyclohex-2-enone extracted and isolated from Streptomyces albus AC18. The crude compound was loaded on silica gel column and eluted with chloroform - methanol - water. The purity of isolated compound were analyzed by TLC using chloroform and methanol as the solvent system and verified by GC-MS. The purified compound structure was established from infrared, ultraviolet, 1H-NMR, 13C-NMR and mass spectral data. The chemical shift assignments for the aliphatic compound from 1H-NMR corresponds to molecular formula as C18H22O. The Bioassay-guided fraction leads to the isolation of compound, was identified as 3-(4-isopropylstyryl)-5-methylcyclohex-2-enone. Hence, this marine isolated S. albus AC18 actino-bacterial compound seem to be more efficient in its antifungal activity and acts as prominent reservoir for novel drug molecules en route for answering several fungal diseases.