Antihypertensive Activity of Aqueous Extract of Adhatoda Vasica in Hypertensive Rats.

S. Prasad, Sailesh Kumar Ghatuary, A. Sarathe, G. Dubey, K. Prajapati, R. Shinde
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引用次数: 2

Abstract

The present study involved the evaluation of effectiveness of aqueous extract of Adhatoda Vasica on blood pressure, Systolic blood pressure, diastolic blood pressure and mean arterial blood pressure in the hypertensive rats. The result of present study was shown that the pretreatment with aqueous extract of adhatoda vasica (100, 200 & 400mg/Kg p.o) for six week and on the day of experiment after administration of aqueous extract of adhatoda Vasica (10, 20 & 40mg/kg i.v.) produced significant reduction in BP, SBP, DBP and MABP at different time interval in dose dependant manner. The positive control, Captopril at the dose of 1mg/kg was shown significant decrease in the elevated blood pressure in Goldblatt model. It reveals that antihypertensive effect observed for aqueous extract of adhatoda vasica in present study due to decrease rennin release and angiotensin II levels: AT1 and AT2 receptors antagonism: inhibition of aldosterone secreation: increased prostaglandin synthesis or inhibition of ACE that is involved in angiotensin II from angiotensin I. -------------------------------------------------------------------------------------------------------------------------------------Date of Submission: xx-xx-xxxx Date of acceptance: xx-xx-xxxx -------------------------------------------------------------------------------------------------------------------------------------
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水提物对高血压大鼠的降压作用。
本研究探讨了水提物对高血压大鼠血压、收缩压、舒张压和平均动脉血压的影响。本研究结果表明,在给药后(10、20、40mg/ Kg静脉滴注),水提物(100、200、400mg/Kg静脉滴注)预处理6周和实验当天,水提物(10、20、40mg/ Kg静脉滴注)对大鼠的血压、收缩压、舒张压和MABP均有不同时间间隔的剂量依赖性降低。阳性对照卡托普利1mg/kg剂量对Goldblatt模型血压升高有显著降低作用。本研究表明,由于降低肾素释放和血管紧张素II水平,本研究中观察到的血管紧张素水提物的降压作用:AT1和AT2受体拮抗;抑制醛固酮分泌;增加前列腺素合成或抑制血管紧张素i中与血管紧张素II有关的ACE -------------------------------------------------------------------------------------------------------------------------------------xx-xx-xxxx验收日期:xx-xx-xxxx -------------------------------------------------------------------------------------------------------------------------------------
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