Infantile Tremor Syndrome: A Case Series

IF 0.2 Q4 PEDIATRICS Journal of pediatric neurology Pub Date : 2023-04-04 DOI:10.1055/s-0043-1769479
A. Saoji, S. Save, S. Rastogi
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Abstract

Abstract Infantile tremor syndrome (ITS) is a rare clinical disorder characterized by coarse tremors, anemia, and regression/delay of development in children around 6 months to 1 year of age belonging to poor socioeconomic strata and on milk-based diet. It accounts for 0.2 to 2% cases in India. No conclusive etiology has been ascertained so far. Nutritional deficiency (like vitamin B12, magnesium, vitamin C, zinc) is the most accepted association. We report six such cases that presented to our hospital with the classical neurological, dermatological, and hematological findings of ITS. Investigations revealed all cases to be vitamin B12 deficient. Two of our cases had corticocerebral atrophy on neuroimaging. One case expired due to respiratory failure due to severe pneumonia. Others were treated with vitamin B12 injections. Other nutrients like iron, zinc, folic acid, and magnesium were also supplemented. Routine follow-up of these cases showed gradual improvement in clinical, hematological, and neurological parameters. Although rare, ITS should be considered in any infant presenting with anemia, malnutrition, developmental delay, hyperpigmentation, and tremors. Early treatment can prevent neurological sequelae as it is largely a preventable disease. Regular follow-up is helpful to evaluate response to treatment.
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婴儿震颤综合征:一个病例系列
婴幼儿震颤综合征(ITS)是一种罕见的临床疾病,其特征为剧烈震颤、贫血和发育倒退/延迟,发生在6个月至1岁左右,属于贫困社会经济阶层和以牛奶为基础的饮食。在印度,它占0.2%到2%的病例。迄今尚未确定确切的病因。营养缺乏(如维生素B12,镁,维生素C,锌)是最被接受的联系。我们报告了6例这样的病例,他们在本院表现为ITS的经典神经学、皮肤学和血液学表现。调查显示,所有病例都缺乏维生素B12。我们的两个病例在神经影像学上表现为皮质脑萎缩。1例因严重肺炎导致呼吸衰竭死亡。其他人则接受维生素B12注射治疗。其他营养物质如铁、锌、叶酸和镁也得到了补充。这些病例的常规随访显示临床、血液学和神经学参数逐渐改善。虽然罕见,但在任何出现贫血、营养不良、发育迟缓、色素沉着和震颤的婴儿中都应考虑ITS。早期治疗可以预防神经系统后遗症,因为它在很大程度上是一种可预防的疾病。定期随访有助于评价治疗效果。
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来源期刊
CiteScore
0.40
自引率
0.00%
发文量
52
期刊介绍: The Journal of Pediatric Neurology is a multidisciplinary peer-reviewed medical journal publishing articles in the fields of childhood neurology, pediatric neurosurgery, pediatric neuroradiology, child psychiatry and pediatric neuroscience. The Journal of Pediatric Neurology, the official journal of the Society of Pediatric Science of the Yüzüncü Yil University in Turkiye, encourages submissions from authors throughout the world. The following articles will be considered for publication: editorials, original and review articles, rapid communications, case reports, neuroimage of the month, letters to the editor and book reviews.
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