Ketoconazole: A Promising Drug for Fungal Infections

Abstract

Ketoconazole is a synthetic imidazole antifungal agent that can be used to treat surface fungal infections, genital, chronic mucocutaneous candidosis, and candidosis. Ketoconazole is a synthetic imidazole derivative that is effective after oral administration, unlike older imidazole antifungals like miconazole and clotrimazole. It works well for fungal infections on the skin, such as dermatophytosis and genital candidiasis. It has become useful for the treatment of persistent mucocutaneous candidiasis. In immunocompromised individuals, ketoconazole is also used to prevent fungal infections. It has lately been utilised as a therapy for advanced prostatic cancer because it inhibits the production of adrenal sex hormone. Although oral ketoconazole has been subjected to labelling modifications and market withdrawal because of substantial adverse effects, topical ketoconazole is widely regarded to be efficacious, safe, and best for treating superficial fungal infections. Onychomycosis, blepharitis, and hair loss are some of the new dermatologic indications for topical ketoconazole usage.