Evaluation of Glycemic, Lipid, Immune-Inflammatory and Oxidative Stress Markers in Various Clinical Stages of Type 2 Diabetic Nephropathy

Abstract

Type 2 Diabetic nephropathy (DN), chronic multifactorial disorder is a devastating complication of DM and a main cause of end stage renal failure. A variety of factors like metabolic, hemodynamic, genetic and multiple pathogenic events contribute to the renal damage in type 2 DN. The present study was designed to assess blood glucose, serum lipid profiles, immune-inflammatory and oxidative stress markers in type 2 DN patients in different stages of the disease and healthy controls. Our study showed that FBS, PPG, HbA1c, TC, TG, LDL-C, ADA, CRP, MDA, NO and DNA damage were significantly high in type 2 DN patients (p<0.01) compared to controls. In stage wise comparison also FBS, PPG, HbA1c, LDL-C, CRP, MDA, NO and DNA damage showed significant difference (p<0.05). Further, a significant positive correlation was found between PLBS, LDL-C and CRP and oxidative stress markers (MDA, NO, DNA damage) suggesting that monitoring these biochemical parameters at regular intervals may reduce the stage wise progression of type 2 DN and might help in early detection, precise prognosis/therapeutic modalities.