Therapeutic effectiveness and development of eugenol topical gel to reduce irritant effect on skin

Abstract

The present study was designed to formulate and evaluate different formulae of topical gel containing eugenol for treatment of skin disorder as acne. The gel was formulation was optimized by using different polymers with different concentration of hydroxyl propyl methyl cellulose (HPMC), carbopol, and xanthan gum. In these all polymer, carbopol polymers were suitable for formulation in different concentration such as 1%, 2% and 3%. Five different formulae were prepared and characterized physically in terms of colour, pH, homogeneity, drug content, in-vitro drug release. Drug was identified by the IR and Mass. These are also identified by UV.