Pub Date : 2022-01-01DOI: 10.54037/wjps.2022.100405
Sachin C. Joshi, Amit V. Kakad, Vardhaman A. Murkunde, Gayatri Kanade
The common cold, influenza, chickenpox, human immunodeficiency virus (HIV), SARS-CoV-2, and other disease-causing (pathogenic) viruses crop up when most people hear the word "virus." Infectious diseases are predicted to account for over one-third (i.e., 20 million) of annual deaths worldwide, as per the World Health Organization (WHO). The rising globalized health sector has made major contributions to the improvement of human health. However, long-standing, developing, and re-emerging infectious disease risks continue to haunt the globe. With a pandemic on the scale of COVID-19, Antibiotic resistance is a veiled concern looming behind the COVID-19 pandemic, which has already claimed thousands of lives before the global breakout. With the worrisome rise in antibiotic resistance incidences only few new antimicrobial drugs on the horizon, it's essential to keep monitor of pathogen epidemiology in ways that will improve treatment decisions. This review article aimed to outline recent findings of the origin, transmission, diagnosis, precautionary measures, antimicrobial resistance, reinfection and repurposing of drugs for the treatment and prevention of COVID-19 depending on the previous literature.
{"title":"Viral Infection-A Looming Catastrophe","authors":"Sachin C. Joshi, Amit V. Kakad, Vardhaman A. Murkunde, Gayatri Kanade","doi":"10.54037/wjps.2022.100405","DOIUrl":"https://doi.org/10.54037/wjps.2022.100405","url":null,"abstract":"The common cold, influenza, chickenpox, human immunodeficiency virus (HIV), SARS-CoV-2, and other disease-causing (pathogenic) viruses crop up when most people hear the word \"virus.\" Infectious diseases are predicted to account for over one-third (i.e., 20 million) of annual deaths worldwide, as per the World Health Organization (WHO). The rising globalized health sector has made major contributions to the improvement of human health. However, long-standing, developing, and re-emerging infectious disease risks continue to haunt the globe. With a pandemic on the scale of COVID-19, Antibiotic resistance is a veiled concern looming behind the COVID-19 pandemic, which has already claimed thousands of lives before the global breakout. With the worrisome rise in antibiotic resistance incidences only few new antimicrobial drugs on the horizon, it's essential to keep monitor of pathogen epidemiology in ways that will improve treatment decisions. This review article aimed to outline recent findings of the origin, transmission, diagnosis, precautionary measures, antimicrobial resistance, reinfection and repurposing of drugs for the treatment and prevention of COVID-19 depending on the previous literature.","PeriodicalId":23975,"journal":{"name":"World journal of Pharmacy and pharmaceutical sciences","volume":"12 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73966046","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.54037/wjps.2022.100208
Sunil Kumar, M. George, L. Joseph
{"title":"Herbal approaches of leaves of the plant maytenus emarginata as anti-inflammatory and anti-nociceptive","authors":"Sunil Kumar, M. George, L. Joseph","doi":"10.54037/wjps.2022.100208","DOIUrl":"https://doi.org/10.54037/wjps.2022.100208","url":null,"abstract":"","PeriodicalId":23975,"journal":{"name":"World journal of Pharmacy and pharmaceutical sciences","volume":"35 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75080116","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.54037/wjps.2022.100108
M. Rohini, M. Ajitha
A simple, Accurate, precise method was developed for the simultaneous estimation of the Metformin and Empagliflozin in Tablet dosage form. Chromatogram was run through Std Symmetry 150 x 4.6 mm, 5. Mobile phase containing 0.1% OPA Buffer: Acetonitrile taken in the ratio 60:40 was pumped through column at a flow rate of 1ml/min. Buffer used in this method was 0.1% OPA buffer. Temperature was maintained at 30°C. Optimized wavelength selected was 230 nm. Retention time of Metformin and Empagliflozin were found to be 2.276min and 2.890min. %RSD of the Metformin and Empagliflozin were and found to be 0.9 and 0.6 respectively. %Recovery was obtained as 100.87% and 100.43% for Metformin and Empagliflozin respectively. LOD, LOQ values obtained from regression equations of Metformin and Empagliflozin were 0.23, 0.75 and 0.01, 0.03 respectively. Regression equation of Metformin is y =27483x + 7407, and y =26728x + 133.3 of Empagliflozin. Retention times were decreased and that run time was decreased, so the method developed was simple and economical that can be adopted in regular Quality control test in Industries.
建立了同时测定片剂中二甲双胍和依帕列净含量的简便、准确、精确的方法。通过Std Symmetry 150 x 4.6 mm, 5运行色谱图。流动相含0.1% OPA缓冲液:乙腈按60:40的比例以1ml/min的流速泵入柱中。本方法所用缓冲液为0.1% OPA缓冲液。温度保持在30°C。优选波长为230 nm。二甲双胍和依帕列净的滞留时间分别为2.276min和2.890min。二甲双胍和依帕列净的RSD分别为0.9和0.6。二甲双胍和依帕列净的回收率分别为100.87%和100.43%。二甲双胍和依帕列净的LOD、LOQ分别为0.23、0.75和0.01、0.03。二甲双胍的回归方程为y =27483x + 7407，恩格列净的回归方程为y =26728x + 133.3。该方法减少了滞留时间，缩短了运行时间，简便、经济，可用于工业中常规的质量控制试验。
{"title":"Stability Indicating Method Development and Validation for Determination of Metforminand Empagliflozin in Bulk and Pharmaceutical Dosage Form by RP-HPLC","authors":"M. Rohini, M. Ajitha","doi":"10.54037/wjps.2022.100108","DOIUrl":"https://doi.org/10.54037/wjps.2022.100108","url":null,"abstract":"A simple, Accurate, precise method was developed for the simultaneous estimation of the Metformin and Empagliflozin in Tablet dosage form. Chromatogram was run through Std Symmetry 150 x 4.6 mm, 5. Mobile phase containing 0.1% OPA Buffer: Acetonitrile taken in the ratio 60:40 was pumped through column at a flow rate of 1ml/min. Buffer used in this method was 0.1% OPA buffer. Temperature was maintained at 30°C. Optimized wavelength selected was 230 nm. Retention time of Metformin and Empagliflozin were found to be 2.276min and 2.890min. %RSD of the Metformin and Empagliflozin were and found to be 0.9 and 0.6 respectively. %Recovery was obtained as 100.87% and 100.43% for Metformin and Empagliflozin respectively. LOD, LOQ values obtained from regression equations of Metformin and Empagliflozin were 0.23, 0.75 and 0.01, 0.03 respectively. Regression equation of Metformin is y =27483x + 7407, and y =26728x + 133.3 of Empagliflozin. Retention times were decreased and that run time was decreased, so the method developed was simple and economical that can be adopted in regular Quality control test in Industries.","PeriodicalId":23975,"journal":{"name":"World journal of Pharmacy and pharmaceutical sciences","volume":"92 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80206118","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.54037/wjps.2021.91211
I.S.V. Manvita, G Sravani, M.Sudhakar, Malathi, B.Bhavani, Janvi Varma, Anusha, Ramya Uppala, Azmira Aktar
Polycystic ovarian disorder (PCOD)isthe mostcommonhormonal disorder seenin females of reproductive worldwide. From the very limited data, PCOD prevalence in India ranges from 3.7% to 22.5%. Polycystic Ovarian disease requires "control" rather than "cure", the treatmentdecisions depend on symptoms, age, whether or not the women wantto becomepregnant.Aim: To study the prevalence of clinical manifestations andhormonal abnormalities associated with PCOD. Methodology: This prospective observational study was carried out in gynaecology department of Mallareddy hospital, where subjects were enrolled based on inclusion and exclusion criteria. All 100 patients demographics were documented. The prevalence of clinical manifestations and hormonal abnormalities in all subjects were assessed.Results: Irregular menstruation was seen as the most common clinical manifestation and seen in maximum 66% of subjects, Hirsutism was seen in 35% of the cases followed by acne in 28% of cases , androgenic alopecia in 22% of cases and acanthosis nigricans in minority 7% of cases .When the subjects were assessed for hormonal abnormalities, 52% of the subjects showed decreased FSH, 48% of the subjects had increased LH, 9% had decreased and33 % had increased PRL, 38% showed increased Testosterone, 21% had decreased and 7% had increased T3, T4 levels.Conclusion: Irregular menstruation was seen as the most common clinical manifestation followed by dermatologic manifestations –Hirsutism, Acne, Acanthosis nigricans and androgenic alopecia.Clinical manifestations diagnosis can lead to early treatment in these patients and helps them in relieving their symptoms and improve qualityof life.
{"title":"A prospective cross sectional observational study on prevalence of clinical manifestations and hormonal abnormalities associated with polycystic ovarian disease","authors":"I.S.V. Manvita, G Sravani, M.Sudhakar, Malathi, B.Bhavani, Janvi Varma, Anusha, Ramya Uppala, Azmira Aktar","doi":"10.54037/wjps.2021.91211","DOIUrl":"https://doi.org/10.54037/wjps.2021.91211","url":null,"abstract":"Polycystic ovarian disorder (PCOD)isthe mostcommonhormonal disorder seenin females of reproductive worldwide. From the very limited data, PCOD prevalence in India ranges from 3.7% to 22.5%. Polycystic Ovarian disease requires \"control\" rather than \"cure\", the treatmentdecisions depend on symptoms, age, whether or not the women wantto becomepregnant.Aim: To study the prevalence of clinical manifestations andhormonal abnormalities associated with PCOD. Methodology: This prospective observational study was carried out in gynaecology department of Mallareddy hospital, where subjects were enrolled based on inclusion and exclusion criteria. All 100 patients demographics were documented. The prevalence of clinical manifestations and hormonal abnormalities in all subjects were assessed.Results: Irregular menstruation was seen as the most common clinical manifestation and seen in maximum 66% of subjects, Hirsutism was seen in 35% of the cases followed by acne in 28% of cases , androgenic alopecia in 22% of cases and acanthosis nigricans in minority 7% of cases .When the subjects were assessed for hormonal abnormalities, 52% of the subjects showed decreased FSH, 48% of the subjects had increased LH, 9% had decreased and33 % had increased PRL, 38% showed increased Testosterone, 21% had decreased and 7% had increased T3, T4 levels.Conclusion: Irregular menstruation was seen as the most common clinical manifestation followed by dermatologic manifestations –Hirsutism, Acne, Acanthosis nigricans and androgenic alopecia.Clinical manifestations diagnosis can lead to early treatment in these patients and helps them in relieving their symptoms and improve qualityof life.","PeriodicalId":23975,"journal":{"name":"World journal of Pharmacy and pharmaceutical sciences","volume":"48 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86997652","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.54037/wjps.2022.100401
Bakyalakshmi M, S. K L, G. P D, K. S., Pattaluchetty P, S. Kumar S
This present work deals with the synthesis of new azo derivative based on reaction between Amino pyridine and Para hydroxy benzoic acid. The synthesized compound was determined by spectrum characterization and screened for Antimicrobial and anthelmintic activity.
{"title":"Synthesis, spectrum characterization and estimation of biological activity of new heterocycylic compound","authors":"Bakyalakshmi M, S. K L, G. P D, K. S., Pattaluchetty P, S. Kumar S","doi":"10.54037/wjps.2022.100401","DOIUrl":"https://doi.org/10.54037/wjps.2022.100401","url":null,"abstract":"This present work deals with the synthesis of new azo derivative based on reaction between Amino pyridine and Para hydroxy benzoic acid. The synthesized compound was determined by spectrum characterization and screened for Antimicrobial and anthelmintic activity.","PeriodicalId":23975,"journal":{"name":"World journal of Pharmacy and pharmaceutical sciences","volume":"125 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78466773","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Diarrhea is a major health problem throughout the world and it has become more problematic in developing countries like Ethiopia. People, in several parts of the world, use different traditional medicines for treating diarrhea and it has been reported that the roots, leaves, and flowers of various species are used for the same purpose. Diarrhea is the second most common cause of death in children under five years. It causes more than 5‐8 million deaths each year in infants and children below 5 years old. An antimicrobial is an agent that kills microorganisms or stops their growth. Antimicrobial medicines can be grouped according to the microorganisms they act primarily against. For example, antibiotics are used against bacteria, and antifungals are used against fungi. Antimicrobial resistance (AMR) is the ability of microorganisms to persist or grow in the presence of drugs designed to inhibit or kill them. These drugs, called antimicrobials, are used to treat infectious diseases caused by microorganisms such as bacteria, fungi, viruses and protozoan parasites.
{"title":"Antimicrobial and Antidiarrheal drugs Survey","authors":"Suthar Mona, Makwana Rajeshree, Jain Priyanshi, Dholekar Ekta","doi":"10.54037/wjps.2022.100403","DOIUrl":"https://doi.org/10.54037/wjps.2022.100403","url":null,"abstract":"Diarrhea is a major health problem throughout the world and it has become more problematic in developing countries like Ethiopia. People, in several parts of the world, use different traditional medicines for treating diarrhea and it has been reported that the roots, leaves, and flowers of various species are used for the same purpose. Diarrhea is the second most common cause of death in children under five years. It causes more than 5‐8 million deaths each year in infants and children below 5 years old. An antimicrobial is an agent that kills microorganisms or stops their growth. Antimicrobial medicines can be grouped according to the microorganisms they act primarily against. For example, antibiotics are used against bacteria, and antifungals are used against fungi. Antimicrobial resistance (AMR) is the ability of microorganisms to persist or grow in the presence of drugs designed to inhibit or kill them. These drugs, called antimicrobials, are used to treat infectious diseases caused by microorganisms such as bacteria, fungi, viruses and protozoan parasites.","PeriodicalId":23975,"journal":{"name":"World journal of Pharmacy and pharmaceutical sciences","volume":"2 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84285995","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.54037/wjps.2022.100601
Owonaro Pa, Eniojukan Jf, Onome E
Sexually transmitted infections (STIs) are mainly transmitted from person-to-person mostly through sexual contact. There are several microorganisms that account for STIs such as bacteria, viruses, and parasites. This study investigated prevalence, pattern of STIs treatment, knowledge, and awareness of STIs among the community pharmacists. A purposive or judgmental sampling technique was used to recruit the community Pharmacist (CPs). Self –report questionnaire, was employed as research tools to achieve the objectives of the study. Ethical approval and permissionswere approved by theBayelsa State Ministry of Health, Ethics Committee, and Community Pharmacist Association, Bayelsa State Chapter. One hundred and thirty (n = 130) questionnaires were given out, and 126 questionnaires were retrieved. The participants were mostly within the age range of 30 to40 years. Therewas high prevalence of STIs. Most of the participants had awareness of the antimicrobials to use as treatment of STIs. There was no statistically significant difference between years of practice and use of antimicrobial in treating STIs (p = 0.68). Ceftriaxone, Azithromycin and ciprofloxacin were the most used antibioticsalways for thetreatment of STIs. Single dose of ceftriaxone was often recommended. Common STIs reported wereGonorrhea and genital wart. There wasno statistically significant difference between years of practice and those reported Gonorrhea and genital warts as the most treated STIs (p = 0.44).The younger age group (18 to34 years)were most affectedwith STIs, and the female proportion was the highestwith STIs. There was a statistically significantdifferencethe those with longer practice experience and those that had few years of practice experience that reported the youngerage group was most affected withSTIs (p <0.0001).STIs most common side effect reported was genital ulcer and pain in the lower abdomen. The CPs often providedpharmaceutical services to their patients with STIs. There was a statically significant difference with those CPs that provided pharmaceutical service and those who did not provide the above related services (p <0.005). The study clearly demonstrated high prevalence of STIs, adequate knowledge of STIs and the treatment of STIs was antimicrobial. There is need for enlightenment campaign among the CPs on the need to follow standard treatment guidelines (STGs) to treat patients with STIs. Also, the need to educate the public on the modes of transmission, prevention and providing information on accessing of condoms are recommended to reduce sexually transmitted infection.Lastly, the use of STGs for the management of STIs should be encouraged among the CPs
{"title":"Prevalence and Management of Sexually Transmitted Infections in Community Pharmacies in Yenagoa Bayelsa State: A Potentially Under-Utilized HIV Prevention Strategy","authors":"Owonaro Pa, Eniojukan Jf, Onome E","doi":"10.54037/wjps.2022.100601","DOIUrl":"https://doi.org/10.54037/wjps.2022.100601","url":null,"abstract":"Sexually transmitted infections (STIs) are mainly transmitted from person-to-person mostly through sexual contact. There are several microorganisms that account for STIs such as bacteria, viruses, and parasites. This study investigated prevalence, pattern of STIs treatment, knowledge, and awareness of STIs among the community pharmacists. A purposive or judgmental sampling technique was used to recruit the community Pharmacist (CPs). Self –report questionnaire, was employed as research tools to achieve the objectives of the study. Ethical approval and permissionswere approved by theBayelsa State Ministry of Health, Ethics Committee, and Community Pharmacist Association, Bayelsa State Chapter. One hundred and thirty (n = 130) questionnaires were given out, and 126 questionnaires were retrieved. The participants were mostly within the age range of 30 to40 years. Therewas high prevalence of STIs. Most of the participants had awareness of the antimicrobials to use as treatment of STIs. There was no statistically significant difference between years of practice and use of antimicrobial in treating STIs (p = 0.68). Ceftriaxone, Azithromycin and ciprofloxacin were the most used antibioticsalways for thetreatment of STIs. Single dose of ceftriaxone was often recommended. Common STIs reported wereGonorrhea and genital wart. There wasno statistically significant difference between years of practice and those reported Gonorrhea and genital warts as the most treated STIs (p = 0.44).The younger age group (18 to34 years)were most affectedwith STIs, and the female proportion was the highestwith STIs. There was a statistically significantdifferencethe those with longer practice experience and those that had few years of practice experience that reported the youngerage group was most affected withSTIs (p <0.0001).STIs most common side effect reported was genital ulcer and pain in the lower abdomen. The CPs often providedpharmaceutical services to their patients with STIs. There was a statically significant difference with those CPs that provided pharmaceutical service and those who did not provide the above related services (p <0.005). The study clearly demonstrated high prevalence of STIs, adequate knowledge of STIs and the treatment of STIs was antimicrobial. There is need for enlightenment campaign among the CPs on the need to follow standard treatment guidelines (STGs) to treat patients with STIs. Also, the need to educate the public on the modes of transmission, prevention and providing information on accessing of condoms are recommended to reduce sexually transmitted infection.Lastly, the use of STGs for the management of STIs should be encouraged among the CPs","PeriodicalId":23975,"journal":{"name":"World journal of Pharmacy and pharmaceutical sciences","volume":"36 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84587758","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.54037/wjps.2022.100202
Aiswarya Reji, Revathy P Vijayan
{"title":"Formulation and characterization of self microemulsifying sustained release pellets for breast cancer","authors":"Aiswarya Reji, Revathy P Vijayan","doi":"10.54037/wjps.2022.100202","DOIUrl":"https://doi.org/10.54037/wjps.2022.100202","url":null,"abstract":"","PeriodicalId":23975,"journal":{"name":"World journal of Pharmacy and pharmaceutical sciences","volume":"44 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82341602","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.54037/wjps.2021.91212
S. Siddiraju, Akshay, M. Sudhakar
A simple, Accurate, precise method was developed for the simultaneous estimation of the Netupitant and Palanosetron in Tablet dosage form. Chromatogram was run through Std Discovery C18 250 x 4.6 mm, 5. Mobile phase containing Buffer 0.1% OPA (2.2ph): Acetonitrile taken in the ratio 55:45 was pumped through column at a flow rate of 1 ml/min. Buffer used in this method was 0.1% OPA. Temperature was maintained at 30°C. Optimized wavelength selected was 230 nm. Retention time of Netupitant and Palanosetron were found to be 2.325min and 3.026min. %RSD of the Netupitant and Palanosetron were and found to be 0.9 and 0.6 respectively. %Recovery was obtained as 100.28% and 99.76% for Netupitant and Palanosetron respectively. LOD, LOQ values obtained from regressionequations of Netupitant and Palanosetron were 1.01, 3.05 and 0.001, 0.003 respectively. Regression equation of Netupitant is y = 13900x + 26511, and y = 563617x + 1740.8 of Palanosetron. Retention times were decreased and that run time was decreased, so the method developed was simple and economical that can be adopted in regular Quality control test in Industries.
{"title":"Method development and validation for simultaneous estimation of netupitant and palonosetron in bulk and pharmaceutical dosage form by using RP-HPLC","authors":"S. Siddiraju, Akshay, M. Sudhakar","doi":"10.54037/wjps.2021.91212","DOIUrl":"https://doi.org/10.54037/wjps.2021.91212","url":null,"abstract":"A simple, Accurate, precise method was developed for the simultaneous estimation of the Netupitant and Palanosetron in Tablet dosage form. Chromatogram was run through Std Discovery C18 250 x 4.6 mm, 5. Mobile phase containing Buffer 0.1% OPA (2.2ph): Acetonitrile taken in the ratio 55:45 was pumped through column at a flow rate of 1 ml/min. Buffer used in this method was 0.1% OPA. Temperature was maintained at 30°C. Optimized wavelength selected was 230 nm. Retention time of Netupitant and Palanosetron were found to be 2.325min and 3.026min. %RSD of the Netupitant and Palanosetron were and found to be 0.9 and 0.6 respectively. %Recovery was obtained as 100.28% and 99.76% for Netupitant and Palanosetron respectively. LOD, LOQ values obtained from regressionequations of Netupitant and Palanosetron were 1.01, 3.05 and 0.001, 0.003 respectively. Regression equation of Netupitant is y = 13900x + 26511, and y = 563617x + 1740.8 of Palanosetron. Retention times were decreased and that run time was decreased, so the method developed was simple and economical that can be adopted in regular Quality control test in Industries.","PeriodicalId":23975,"journal":{"name":"World journal of Pharmacy and pharmaceutical sciences","volume":"42 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87123113","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.54037/wjps.2022.100305
Tarun Pandey, J. Mishra, D. K. Vishwakarma
The present study was designed to formulate and evaluate different formulae of topical gel containing eugenol for treatment of skin disorder as acne. The gel was formulation was optimized by using different polymers with different concentration of hydroxyl propyl methyl cellulose (HPMC), carbopol, and xanthan gum. In these all polymer, carbopol polymers were suitable for formulation in different concentration such as 1%, 2% and 3%. Five different formulae were prepared and characterized physically in terms of colour, pH, homogeneity, drug content, in-vitro drug release. Drug was identified by the IR and Mass. These are also identified by UV.
{"title":"Therapeutic effectiveness and development of eugenol topical gel to reduce irritant effect on skin","authors":"Tarun Pandey, J. Mishra, D. K. Vishwakarma","doi":"10.54037/wjps.2022.100305","DOIUrl":"https://doi.org/10.54037/wjps.2022.100305","url":null,"abstract":"The present study was designed to formulate and evaluate different formulae of topical gel containing eugenol for treatment of skin disorder as acne. The gel was formulation was optimized by using different polymers with different concentration of hydroxyl propyl methyl cellulose (HPMC), carbopol, and xanthan gum. In these all polymer, carbopol polymers were suitable for formulation in different concentration such as 1%, 2% and 3%. Five different formulae were prepared and characterized physically in terms of colour, pH, homogeneity, drug content, in-vitro drug release. Drug was identified by the IR and Mass. These are also identified by UV.","PeriodicalId":23975,"journal":{"name":"World journal of Pharmacy and pharmaceutical sciences","volume":"541 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85662664","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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