Comparación entre el uso de corifolitropina alfa frente a gonadotropinas convencionales en pacientes con diagnóstico de baja respuesta ovárica según los criterios de Bolonia

Abstract

Introduction

Gonadotropin-releasing hormones are not only more comfortable as an assisted reproduction treatment, but also have the pharmacokinetics that could benefit poor responders to ovarian stimulation. A comparison is made with the results from the use of corifollitropin in patients with cycles produced with conventional gonadotropins.

Material and methods

An analysis was performed on the results obtained after stimulating the same group of patients with low ovarian reserve, according to Bologna criteria, with conventional gonadotropins versus corifollitropin alpha. The number of mature oocytes collected was the primary study variable.

Results

It was found that the use of corifollitropin alpha in patients with a diagnosis of low ovarian response is at least as effective as the conventional gonadotropin regimens given daily.

Discussion

With our results it can be conclude that offering corifollitropin to poor responders is at least as efficient as conventional gonadotropins, but it adds several advantages in terms of comfort and dosage.