S. Lai, B. Tao, S. Fu, G. He, Y. Wei, Jingshun Zhang, Yiping Ren
{"title":"Determination of 29 kinds of estrogens in milk and milk products by liquid chromatography tandem mass spectrometry.","authors":"S. Lai, B. Tao, S. Fu, G. He, Y. Wei, Jingshun Zhang, Yiping Ren","doi":"10.3724/sp.j.1096.2012.11102","DOIUrl":null,"url":null,"abstract":"A method was developed for the determination of 29 kinds of estrogens in milk and milk products by liquid chromatography tandem mass spectrometry. The sample was deposited protein with acetonitrile and extracted with ethyl acetate. then passed through HLB cartridge to clear-up. The test potion was separated by Shield RP18 and HSS T3 columns with gradient elution program and the results were calculated by internal standard method. the LODs were 0.1-0.5 µg/kg, the recoveries were 70%-120% with 1%-20% of RSD. This method has good reproducibility, high accuracy, low cost and is suitable for routine sample testing.","PeriodicalId":7832,"journal":{"name":"Analytical Abstracts","volume":"11 1","pages":"135-139"},"PeriodicalIF":0.0000,"publicationDate":"2012-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Analytical Abstracts","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.3724/sp.j.1096.2012.11102","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
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Abstract
A method was developed for the determination of 29 kinds of estrogens in milk and milk products by liquid chromatography tandem mass spectrometry. The sample was deposited protein with acetonitrile and extracted with ethyl acetate. then passed through HLB cartridge to clear-up. The test potion was separated by Shield RP18 and HSS T3 columns with gradient elution program and the results were calculated by internal standard method. the LODs were 0.1-0.5 µg/kg, the recoveries were 70%-120% with 1%-20% of RSD. This method has good reproducibility, high accuracy, low cost and is suitable for routine sample testing.
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