Assessment of WBCs, CRP, LDH and other Biomarkers of Moderate and Severe COVID-19 Patients in Iraq

M. Salman, Ansam Atwan Abdulah
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Abstract

Background: Though most Iraqi patients who are infected by COVID-19 only suffering from mild symptoms, but in some cases a patient’s condition deteriorates, leading to a negative outcome. This study aims to assess the clinical laboratory features of moderate and severe COVID-19 patients Methods: One hundred diagnosed as moderate and severe COVID-19 patients as well as fifty healthy participants were involved in our current study. Assessment was made for WBCs, Monocytes, Lymphocyte, and Platelets. In addition, serum levels of lactate dehydrogenase (LDH) and C-reactive protein (CRP). Results: A hundred patients aged 33 to 70 years with COVID-19 had severe and moderate cases. Present in DAR AL-SALAM for COVID-19 isolation in Baghdad, Iraq. COVID-19 patients showed increased serum levels LDH and CRP as well as WBCs count and others when compared to healthy individuals. The severe group showed a statistically significant increase in WBCs account, neutrophil activity and LDH levels, compared with moderate group. While the moderate COVID-19 groups displayed a significant rise in lymphocytes activity, CRP, and Platelet. Conclusion: The current investigation found that WBC count, lymphocyte count, LDH activity, and CRP level were effective indicators for determining the severity of COVID-19, making them good assessment indicators.
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伊拉克中重度新冠肺炎患者白细胞、CRP、LDH等生物标志物检测
背景:虽然大多数感染新冠病毒的伊拉克患者只有轻微症状,但在某些情况下,患者的病情恶化,导致负面结果。本研究旨在评估中、重度新冠肺炎患者的临床实验室特征。方法:本研究纳入100例诊断为中、重度新冠肺炎患者和50例健康受试者。评估白细胞、单核细胞、淋巴细胞和血小板。此外,血清乳酸脱氢酶(LDH)和c反应蛋白(CRP)水平。结果:100例33 ~ 70岁的新型冠状病毒肺炎患者中有重度和中度病例。在伊拉克巴格达进行COVID-19隔离。与健康个体相比,COVID-19患者的血清LDH和CRP水平以及白细胞计数等均有所增加。与中度组相比,重度组白细胞计数、中性粒细胞活性和LDH水平均有统计学意义的升高。而中度COVID-19组淋巴细胞活性、CRP和血小板显著升高。结论:本研究发现WBC计数、淋巴细胞计数、LDH活性、CRP水平是判断COVID-19严重程度的有效指标,是较好的评价指标。
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