Measurements and monitorings dependent color intensity of drugs and food supplements interactions with textile dyes between TLC plates by using rope printing technique

Abstract

The discussions of pharmacokinetic and pharmacodynamic interactions between drugs and medicinal plants has been put forward, especially with medicinal herbs that can interact with antidiabetic drugs. In addition to their treatment, many diabetic patients are known to use herbal medicines that have both antidiabetic effects and potential benefits.1 Approximately 72.8% of people with diabetes use herbal medicine and dietary supplements.2 Interactions between herbal mixtures and medicines may increase the effectiveness of antidiabetic agents. For example, antidiabetic drugs have been shown to increase blood glucose-lowering effects with agrimony.3 Many anti-diabetic drugs are substrates of the CYP450 enzyme system, and many medicinal plants may also affect this system. For example, ginkgo inhibits CYP3A4, CYP2C9 and CYP2C19, while St John’s wort inhibits CYP2C and CYP3A.4 Some of the commonly used antidiabetic drugs include pancreatic beta-cell receptors, α-glucosidase inhibitors, e.g., acarbose, peroxisome proliferator activated receptor activators, e.g., thiazolidindiones.5 Many of these plants which include bio-active molecules such as peptides, alkaloids, lipids, terpenoids, amines, sulphur compounds, coumarins, steroids, flavonoids, and inorganic ions, have been used in traditional medicine as antidiabetics.6 As the use of herbal medicines increases, short-term or long-term toxicity due to side effects, overdose, hypersensitivity can be detected by pharmacodynamics or pharmacovigilance.7 In 2010, as a good example practice, the Upsala monitoring center created a database of 4 million reports on about approximately 21000 herbal products from 100 countries in the World.7 In the US, herbal products are classified as botanicals or dietary supplements, not medicines. In Europe, the definition of a herbal product as a food or medicine may have a significant effect on pharmacovigilance, as there is no legal requirement for food supplements.7 Classifications of adverse reactions of herbal medicines in orthodox medicine were formed as Type A (acute); dose-dependent, Type B (specific); not dose-dependent, Type C (chronic): cumulative effect, Type D (onset); genotoxic, carcinogenic.8