Survey of Antagonistic Action and the Mechanism of these Actions that Terpens, Phenols and their Derivatives Possess Against Different Pathogenic Agents

Ali Muayyed Najem
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Abstract

Folk medicine or herbal treatment has been used for centuries by different ancient civilizations against various ailment agents, herbal medicine has been dragged attention by researchers in different medical branches focusing on therapeutically characteristic features of each plant against different pathogenic agents responsible for most devastating and terrifying diseases, in addition to thorough investigation for the phytochemical compounds in each plant responsible for its potent against pathogens. Thus, this study highlights on two major groups of secondary metabolic compounds: terpens, phenols and their derivatives as antimicrobial agents against different bacterial and fungal strains especially drug resistant bacteria which responsible for the infectivity of treatments of most infectious diseases. Furthermore, mechanisms of actions of these secondary metabolites are reviewed as the causative factors responsible for the antimicrobial activity of plants and the promising results which have been achieved in multiply these activities by making combination between these natural products and chemical drugs.
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萜烯类、酚类及其衍生物对不同病原的拮抗作用及其机制研究进展
几个世纪以来,民间医学或草药治疗一直被不同的古代文明用于治疗各种疾病,草药一直受到不同医学分支的研究人员的关注,他们专注于每种植物的治疗特征,以对抗导致最具破坏性和可怕疾病的不同病原体,此外,对每一种植物的化学成分进行彻底的调查,以确定其抗病原体的能力。因此,本研究重点介绍了两大类次生代谢化合物:萜类化合物、酚类化合物及其衍生物作为抗不同细菌和真菌菌株的抗菌剂,特别是耐药细菌,它们对大多数传染病的治疗具有传染性。综述了这些次生代谢物作为植物抗菌活性的致病因子的作用机制,以及将这些天然产物与化学药物结合以增加其抗菌活性所取得的可喜成果。
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