Comparative Phylogenetics Approach for Discovering Alternative Source of Taxol

S. Kushwaha, P. Chauhan, M. Shakya
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Abstract

Bioprospecting is one of the prominent areas of research of commercial and valuable compounds, as it provides alternative sources of these compounds. One of the most persuasive methods for bioprospecting is through molecular phylogenetics analysis. Enzymes involved in the biosynthetic pathway of these compounds are considered as a base for bioprospecting. In this paper, an attempt has been made to find alternative sources for valuable compound taxol by comparative phylogenetics analysis using enzymes physiochemical data and sequence data. Dendogram was generated through physiochemical data whereas phylogenetic tree was generated through sequence data. Consequently after comparison four different organisms, Fungal BT2, OzoniumT2, Abies grandis and Ginkgo biloba, have been observed to be related to taxus plants both sequencially and physiochemically.
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发现紫杉醇替代来源的比较系统发育方法
生物勘探是商业和有价值化合物研究的重要领域之一,因为它提供了这些化合物的替代来源。分子系统发育分析是生物勘探最有说服力的方法之一。参与这些化合物生物合成途径的酶被认为是生物勘探的基础。本文利用酶的理化数据和序列数据对紫杉醇进行系统发育比较分析,试图寻找有价值的化合物紫杉醇的替代来源。通过理化数据生成树突图,通过序列数据生成系统发育树。因此,通过对真菌BT2、OzoniumT2、冷杉(Abies grandis)和银杏(Ginkgo biloba) 4种生物的比较,发现它们在序列和生理化学上都与红豆杉属植物有亲缘关系。
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