Botulinum toxin A for palmar hyperhidrosis: assessment with sympathetic skin responses evoked by train of stimuli

J.Y. Al-Hashel, D. Youssry, H.M. Rashaed, T. Shamov, R.T. Rousseff
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引用次数: 3

Abstract

  1. Objective assessment of the effect of botulinum toxin A (BT) treatment in primary palmar hyperhidrosis (PH) is attempted by different methods.
  2. We decided to use for this purpose sympathetic skin responses evoked by train of stimuli (TSSR).
  3. Twenty patients with severe PH (five female, median age 24, range 18-36) were examined regularly over 3 months after receiving 50 UI BT in each palm. TSSR were recorded from the palms after sensory stimulation by a train of three supramaximal electric pulses 3 millisecond apart. Results were compared to longitudinally studied TSSR of 20 healthy sex- and age-matched control subjects.
  4. All hyperhidrosis patients reported excellent improvement. TSSR amplitudes decreased at week 1 (mean 54% range 48%-67%) and over the following months in a clinically significant trend (slope R=−.82, P<.0001). TSSR in controls changed insignificantly (±13% from the baseline). The difference between patients and controls was highly significant at any time point (P<.001).
  5. This study suggests that TSSR may help in assessment of treatments in PH. It confirms objectively the efficacy of BT in PH.
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A型肉毒毒素治疗手掌多汗症:一系列刺激引起的交感皮肤反应的评估
本文尝试用不同的方法客观评价肉毒毒素A (BT)治疗原发性掌多汗症(PH)的效果。我们决定为此目的使用由刺激序列(TSSR)引起的交感皮肤反应。20例重度PH患者(5名女性,中位年龄24岁,年龄范围18-36岁)在每手掌接受50次ubt治疗后3个多月定期检查。在三组间隔3毫秒的超高压电脉冲刺激手掌后,记录下TSSR。将结果与20名性别和年龄相匹配的健康对照者的TSSR纵向研究结果进行比较。所有多汗症患者均报告了良好的改善。TSSR振幅在第1周下降(平均54%范围为48%-67%),并在接下来的几个月内呈临床显著趋势(斜率R= -)。82年,术中;。)。对照组TSSR变化不显著(与基线相比±13%)。在任何时间点,患者和对照组之间的差异都非常显著(P<.001)。本研究提示TSSR可能有助于PH治疗的评价,客观地证实了BT治疗PH的疗效。
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Issue Information Autonomic and Autacoid Pharmacology: Goodbye and thank you Attenuation of the anti-contractile effect of cooling in the rat aorta by perivascular adipose tissue Retraction: Dopamine receptor immunohistochemistry in the rat choroid plexus. Issue Information
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