Botulinum toxin A for palmar hyperhidrosis: assessment with sympathetic skin responses evoked by train of stimuli

J.Y. Al-Hashel, D. Youssry, H.M. Rashaed, T. Shamov, R.T. Rousseff
{"title":"Botulinum toxin A for palmar hyperhidrosis: assessment with sympathetic skin responses evoked by train of stimuli","authors":"J.Y. Al-Hashel,&nbsp;D. Youssry,&nbsp;H.M. Rashaed,&nbsp;T. Shamov,&nbsp;R.T. Rousseff","doi":"10.1111/aap.12050","DOIUrl":null,"url":null,"abstract":"<div>\n \n <p>\n \n </p><ol>\n \n \n <li>Objective assessment of the effect of botulinum toxin A (BT) treatment in primary palmar hyperhidrosis (PH) is attempted by different methods.</li>\n \n \n <li>We decided to use for this purpose sympathetic skin responses evoked by train of stimuli (TSSR).</li>\n \n \n <li>Twenty patients with severe PH (five female, median age 24, range 18-36) were examined regularly over 3 months after receiving 50 UI BT in each palm. TSSR were recorded from the palms after sensory stimulation by a train of three supramaximal electric pulses 3 millisecond apart. Results were compared to longitudinally studied TSSR of 20 healthy sex- and age-matched control subjects.</li>\n \n \n <li>All hyperhidrosis patients reported excellent improvement. TSSR amplitudes decreased at week 1 (mean 54% range 48%-67%) and over the following months in a clinically significant trend (slope <i>R</i>=−.82, <i>P</i>&lt;.0001). TSSR in controls changed insignificantly (±13% from the baseline). The difference between patients and controls was highly significant at any time point (<i>P</i>&lt;.001).</li>\n \n \n <li>This study suggests that TSSR may help in assessment of treatments in PH. It confirms objectively the efficacy of BT in PH.</li>\n </ol>\n \n </div>","PeriodicalId":100151,"journal":{"name":"Autonomic and Autacoid Pharmacology","volume":"36 3-4","pages":"23-26"},"PeriodicalIF":0.0000,"publicationDate":"2016-11-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/aap.12050","citationCount":"3","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Autonomic and Autacoid Pharmacology","FirstCategoryId":"1085","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1111/aap.12050","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 3

Abstract

  1. Objective assessment of the effect of botulinum toxin A (BT) treatment in primary palmar hyperhidrosis (PH) is attempted by different methods.
  2. We decided to use for this purpose sympathetic skin responses evoked by train of stimuli (TSSR).
  3. Twenty patients with severe PH (five female, median age 24, range 18-36) were examined regularly over 3 months after receiving 50 UI BT in each palm. TSSR were recorded from the palms after sensory stimulation by a train of three supramaximal electric pulses 3 millisecond apart. Results were compared to longitudinally studied TSSR of 20 healthy sex- and age-matched control subjects.
  4. All hyperhidrosis patients reported excellent improvement. TSSR amplitudes decreased at week 1 (mean 54% range 48%-67%) and over the following months in a clinically significant trend (slope R=−.82, P<.0001). TSSR in controls changed insignificantly (±13% from the baseline). The difference between patients and controls was highly significant at any time point (P<.001).
  5. This study suggests that TSSR may help in assessment of treatments in PH. It confirms objectively the efficacy of BT in PH.
查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
A型肉毒毒素治疗手掌多汗症:一系列刺激引起的交感皮肤反应的评估
本文尝试用不同的方法客观评价肉毒毒素A (BT)治疗原发性掌多汗症(PH)的效果。我们决定为此目的使用由刺激序列(TSSR)引起的交感皮肤反应。20例重度PH患者(5名女性,中位年龄24岁,年龄范围18-36岁)在每手掌接受50次ubt治疗后3个多月定期检查。在三组间隔3毫秒的超高压电脉冲刺激手掌后,记录下TSSR。将结果与20名性别和年龄相匹配的健康对照者的TSSR纵向研究结果进行比较。所有多汗症患者均报告了良好的改善。TSSR振幅在第1周下降(平均54%范围为48%-67%),并在接下来的几个月内呈临床显著趋势(斜率R= -)。82年,术中;。)。对照组TSSR变化不显著(与基线相比±13%)。在任何时间点,患者和对照组之间的差异都非常显著(P<.001)。本研究提示TSSR可能有助于PH治疗的评价,客观地证实了BT治疗PH的疗效。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 去求助
来源期刊
自引率
0.00%
发文量
0
期刊最新文献
Issue Information Autonomic and Autacoid Pharmacology: Goodbye and thank you Attenuation of the anti-contractile effect of cooling in the rat aorta by perivascular adipose tissue Retraction: Dopamine receptor immunohistochemistry in the rat choroid plexus. Issue Information
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1