Formulation and evaluation of oxymel containing fenugreek extract

Deepa Sarvan Mudaliyar, Sanika Datta Chavan, Soni Ashok Kushwaha, Rudra prasadrao Eppili, Shivani Bharat Khaladkar, Shriniwas Pramod Patil
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Abstract

Introduction: Trigonella foenum-graecum is medicinal plant of family Fabaceae, consists of bitter principles and traditionally used in treatment of diabetes and hepatoprotective. To mask its bitter taste, it could be formulated in honey based oral formulations like oxymel. Honey, as a saturated solution of various sugars, as per Ayurvedic system of medicine, could be consumed along with drug. This research attempt was aimed towards aqueous extraction of fenugreek seeds; formulation of oxymel by addition to honey and evaluation for different parameters. Oxymel was formulated as per procedure mentioned in United State Pharmacopeia for squill oxymel; and evaluated for pharmaceutical parameters those applied for oral syrups. Results: The oxymel formulated was pale brownish with agreeable odour and sweet taste. It was pourable with viscosity of 80 CP measured at 100 rpm while density was found to be 1.47 g/cm³. There was also ease in cap opening of its container, also no crystallization of honey was observed. Its trigonelline content was found to be 3.6 µg/ml. Conclusion: Alkaloids of fenugreek have significant pharmacological activities in human being, if administered orally. To mask their bitter taste and facilitate their increase in absorption, Trigonella foenum-graecum can successfully be formulated in honey based oral formulation of oxymel.
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含胡芦巴提取物氧梅尔的配方及评价
简介:三角Trigonella foenum-graecum是豆科药用植物,由苦原理组成,传统上用于治疗糖尿病和保肝。为了掩盖它的苦味,它可以被制成以蜂蜜为基础的口服配方,比如oxymel。根据阿育吠陀医学体系,蜂蜜是各种糖的饱和溶液,可以和药物一起服用。本研究旨在对胡芦巴种子进行水提;蜂蜜加氧梅尔的配方及不同参数的评价。Oxymel按照美国药典中提到的程序配制。并对用于口服糖浆的药物参数进行了评价。结果:该制剂为淡棕色,气味宜人,口感甘甜。浇注时粘度为80 CP,转速为100 rpm,密度为1.47 g/cm³。在其容器的盖子打开也很容易,也没有观察到蜂蜜的结晶。其葫芦巴碱含量为3.6µg/ml。结论:胡芦巴生物碱具有显著的药理活性。为了掩盖它们的苦味并促进它们的吸收,可以成功地在蜂蜜为基础的口服oxymel配方中配制茴香草。
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