The proposed mechanism of action of Brucea javanica (L) Merr seed in experimentally diabetic rats

PROCEEDINGS OF THE 2ND INTERNATIONAL CONFERENCE ON BIOSCIENCE, BIOTECHNOLOGY, AND BIOMETRICS 2019 Pub Date : 2019-12-23 DOI:10.1063/1.5141314

H. Muliasari, Candra D Hamdin, Nidaul Aulia, I. Hariyati, M. Ihsan

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引用次数: 2

Abstract

Brucea javanica (L) Merr, locally called “Wali”, is a plant traditionally used to treat diabetes mellitus by local people in Lombok. The people daily consumed the seed to control the blood glucose into normal level. However, the mechanism of action of Wali seed as antidiabetic agent was still unclear. Hence, in this study we investigate the proposed mechanism of action of Wali seed suspensed and ethanolic extract trough measuring the glycogen content in liver and muscles and observing the pancreatic histology of diabetic rats. Wali seed extract (dose 20 and 30 mg/kg BW) and suspense (25 and 50 mg/kg BW) have comparable antidiabetic activity with glibenclamide. Treatments of Wali seed extract and suspense showed dramatically higher glycogen level both in liver and muscles than all controls. Treatment with glibenclamide and Wali seed extract and suspense the pancreas to normal architecture, regeneration of β-cell and enhanced morphology of the β- cells in the islets of Langerhans. The proposed mechanism of action of Wali seed extract and suspense is by converting blood glucose to glycogen storage trough glycogenesis and by recovering the islets of Langerhans of pancreas damage.Brucea javanica (L) Merr, locally called “Wali”, is a plant traditionally used to treat diabetes mellitus by local people in Lombok. The people daily consumed the seed to control the blood glucose into normal level. However, the mechanism of action of Wali seed as antidiabetic agent was still unclear. Hence, in this study we investigate the proposed mechanism of action of Wali seed suspensed and ethanolic extract trough measuring the glycogen content in liver and muscles and observing the pancreatic histology of diabetic rats. Wali seed extract (dose 20 and 30 mg/kg BW) and suspense (25 and 50 mg/kg BW) have comparable antidiabetic activity with glibenclamide. Treatments of Wali seed extract and suspense showed dramatically higher glycogen level both in liver and muscles than all controls. Treatment with glibenclamide and Wali seed extract and suspense the pancreas to normal architecture, regeneration of β-cell and enhanced morphology of the β- cells in the islets of Langerhans. The proposed mechanism of ...

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鸦胆子对实验性糖尿病大鼠的作用机制

鸦嘴草(L) Merr，当地称为“Wali”，是龙目岛当地人传统上用来治疗糖尿病的植物。人们每天食用这种种子，将血糖控制在正常水平。然而，瓦利子作为抗糖尿病药的作用机制尚不清楚。因此，本研究通过测定糖尿病大鼠肝脏和肌肉中的糖原含量，观察胰腺组织学，探讨瓦利子悬浮液和乙醇提取物的作用机制。Wali籽提取物(剂量为20和30 mg/kg BW)和悬浮液(剂量为25和50 mg/kg BW)的抗糖尿病活性与格列本脲相当。试验组肝脏和肌肉糖原水平均显著高于对照组。格列本脲和瓦利籽提取物可使胰岛β细胞再生和形态增强，使胰岛结构恢复正常。其作用机制可能是通过糖生成将血糖转化为糖原储存，并恢复胰腺损伤的朗格汉斯胰岛。鸦嘴草(L) Merr，当地称为“Wali”，是龙目岛当地人传统上用来治疗糖尿病的植物。人们每天食用这种种子，将血糖控制在正常水平。然而，瓦利子作为抗糖尿病药的作用机制尚不清楚。因此，本研究通过测定糖尿病大鼠肝脏和肌肉中的糖原含量，观察胰腺组织学，探讨瓦利子悬浮液和乙醇提取物的作用机制。Wali籽提取物(剂量为20和30 mg/kg BW)和悬浮液(剂量为25和50 mg/kg BW)的抗糖尿病活性与格列本脲相当。试验组肝脏和肌肉糖原水平均显著高于对照组。格列本脲和瓦利籽提取物可使胰岛β细胞再生和形态增强，使胰岛结构恢复正常。提出的机制是……

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PROCEEDINGS OF THE 2ND INTERNATIONAL CONFERENCE ON BIOSCIENCE, BIOTECHNOLOGY, AND BIOMETRICS 2019

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