The Use of Alpelisib in Metastatic Estrogen-Receptor-Positive HER2/Neu-Negative Breast Cancer

D. Yukalchuk, D. M. Ponomarenko, T.N. Yukalchuk, S. S. Sidorova, A.V. Shevchuk, A. Novopashin
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Abstract

The clinical case presented in the article demonstrates the effectiveness of orange in combination with fulvestrant in metastatic estrogen receptor-positive HER2/neu-negative breast cancer with a mutation in the PIK3CA gene. The resistance of hormone therapy requires the search for new therapeutic options. The results of the SOLAR-1 and BYLieve studies have shown not only the effectiveness of alpelisib, but also new types of toxicity characteristic of this therapy. At the moment, recommendations have been developed for the prevention and treatment of the most frequent adverse events, allowing the drug to be used as safely as possible. With the introduction of alpelisib, the possibilities of non-chemotherapeutic treatment options for prognostically unfavorable patients have not only expanded, but there has also been a trend towards the use of personalized medicine and targeted therapy.
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Alpelisib在转移性雌激素受体阳性HER2/新阴性乳腺癌中的应用
本文提出的临床病例证明了橙汁联合氟维西汀治疗转移性雌激素受体阳性HER2/新阴性乳腺癌PIK3CA基因突变的有效性。激素治疗的抗药性要求寻找新的治疗方案。SOLAR-1和BYLieve的研究结果不仅显示了alpelisib的有效性,而且还显示了该疗法的新型毒性特征。目前,已经制定了预防和治疗最常见不良事件的建议,使该药物能够尽可能安全地使用。随着alpelisib的引入,预后不良患者的非化疗治疗选择的可能性不仅扩大了,而且还出现了使用个性化药物和靶向治疗的趋势。
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