Hepatoprotective Potentials of Aqueous extracts of Ficus asperifolia MIQ leaves on CCl4 induced liver damage in Wistar rats

Abstract

The hepatoprotective effect of aqueous leaf extracts of Ficus asperifolia was investigated in rat model of liver injury induced by carbon tetrachloride (CC14). An aliquot of 50mg/kg, 100mg/kg, 200mg/kg and 300mg/kg body weight of extracts of f. asperfolia was used in the treatment of separate rat groups for 4 weeks after liver damage was established. The hepatic status was monitored using lipid per oxidation with malondialdehyde (MDA) as a marker, Liver marker enzymes (Alanine aminotransferase (ALT), Aspartate aminotransferase (AST), Alkaline phosphatase (ALP)) as well as other biochemistry tests (albumin, total protein, globulin and bilirubin level) measured weekly. A significant rise in the various markers were observed after liver damage was induced. Treatment with various concoction of the plants extract showed significant reversal of these parameters when compared with the negative control group (p<0.05). However rats with CCl4 induced liver damage showed dose dependent improved liver conditions while being treated with aqueous leaf extract of F. asperifolia. The group treated with 300mg/kg extract however showed best results. Histopathological investigations supported obtained results. F.asperifolia may therefore be biochemically significant in reversing hepatotoxicity caused by CCl4 and may thus be useful in the treatment of liver damage.