Zaheer Nabi, Rupjyoti Talukdar, Sundeep Lakhtakia, D Nageshwar Reddy
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引用次数: 0
Abstract
Purpose: Endoscopic drainage is an established treatment modality for adult patients with pancreatic fluid collections (PFCs). Available data regarding the efficacy and safety of endoscopic drainage in pediatric patients are limited. In this systematic review and meta-analysis, we aimed to analyze the outcomes of endoscopic drainage in children with PFCs.
Methods: A literature search was performed in Embase, PubMed, and Google Scholar for studies on the outcomes of endoscopic drainage with or without endoscopic ultrasonography (EUS) guidance in pediatric patients with PFCs from inception to May 2021. The study's primary objective was clinical success, defined as resolution of PFCs. The secondary outcomes included technical success, adverse events, and recurrence rates.
Results: Fourteen studies (187 children, 70.3% male) were included in this review. The subtypes of fluid collection included pseudocysts (60.3%) and walled-off necrosis (39.7%). The pooled technical success rates in studies where drainage of PFCs were performed with and without EUS guidance were 95.3% (95% confidence interval [CI], 89.6-98%; I2=0) and 93.9% (95% CI, 82.6-98%; I2=0), respectively. The pooled clinical success after one and two endoscopic interventions were 88.7% (95% CI, 82.7-92.9%; I2=0) and 92.3% (95% CI, 87.4-95.4%; I2=0), respectively. The pooled rate of major adverse events was 6.3% (95% CI, 3.3-11.4%; I2=0). The pooled rate of recurrent PFCs after endoscopic drainage was 10.4% (95% CI, 6.1-17.1%; I2=0).
Conclusion: Endoscopic drainage is safe and effective in children with PFCs. However, future studies are required to compare endoscopic and EUS-guided drainage of PFCs in children.
期刊介绍:
The ACM Special Interest Group on Programming Languages explores programming language concepts and tools, focusing on design, implementation, practice, and theory. Its members are programming language developers, educators, implementers, researchers, theoreticians, and users. SIGPLAN sponsors several major annual conferences, including the Symposium on Principles of Programming Languages (POPL), the Symposium on Principles and Practice of Parallel Programming (PPoPP), the Conference on Programming Language Design and Implementation (PLDI), the International Conference on Functional Programming (ICFP), the International Conference on Object-Oriented Programming, Systems, Languages, and Applications (OOPSLA), as well as more than a dozen other events of either smaller size or in-cooperation with other SIGs. The monthly "ACM SIGPLAN Notices" publishes proceedings of selected sponsored events and an annual report on SIGPLAN activities. Members receive discounts on conference registrations and free access to ACM SIGPLAN publications in the ACM Digital Library. SIGPLAN recognizes significant research and service contributions of individuals with a variety of awards, supports current members through the Professional Activities Committee, and encourages future programming language enthusiasts with frequent Programming Languages Mentoring Workshops (PLMW).