Outcomes of Endoscopic Drainage in Children with Pancreatic Fluid Collections: A Systematic Review and Meta-Analysis.

Q1 Computer Science ACM Sigplan Notices Pub Date : 2022-05-01 Epub Date: 2022-05-09 DOI:10.5223/pghn.2022.25.3.251
Zaheer Nabi, Rupjyoti Talukdar, Sundeep Lakhtakia, D Nageshwar Reddy
{"title":"Outcomes of Endoscopic Drainage in Children with Pancreatic Fluid Collections: A Systematic Review and Meta-Analysis.","authors":"Zaheer Nabi, Rupjyoti Talukdar, Sundeep Lakhtakia, D Nageshwar Reddy","doi":"10.5223/pghn.2022.25.3.251","DOIUrl":null,"url":null,"abstract":"<p><strong>Purpose: </strong>Endoscopic drainage is an established treatment modality for adult patients with pancreatic fluid collections (PFCs). Available data regarding the efficacy and safety of endoscopic drainage in pediatric patients are limited. In this systematic review and meta-analysis, we aimed to analyze the outcomes of endoscopic drainage in children with PFCs.</p><p><strong>Methods: </strong>A literature search was performed in Embase, PubMed, and Google Scholar for studies on the outcomes of endoscopic drainage with or without endoscopic ultrasonography (EUS) guidance in pediatric patients with PFCs from inception to May 2021. The study's primary objective was clinical success, defined as resolution of PFCs. The secondary outcomes included technical success, adverse events, and recurrence rates.</p><p><strong>Results: </strong>Fourteen studies (187 children, 70.3% male) were included in this review. The subtypes of fluid collection included pseudocysts (60.3%) and walled-off necrosis (39.7%). The pooled technical success rates in studies where drainage of PFCs were performed with and without EUS guidance were 95.3% (95% confidence interval [CI], 89.6-98%; <i>I</i> <sup>2</sup>=0) and 93.9% (95% CI, 82.6-98%; <i>I</i> <sup>2</sup>=0), respectively. The pooled clinical success after one and two endoscopic interventions were 88.7% (95% CI, 82.7-92.9%; <i>I</i> <sup>2</sup>=0) and 92.3% (95% CI, 87.4-95.4%; <i>I</i> <sup>2</sup>=0), respectively. The pooled rate of major adverse events was 6.3% (95% CI, 3.3-11.4%; <i>I</i> <sup>2</sup>=0). The pooled rate of recurrent PFCs after endoscopic drainage was 10.4% (95% CI, 6.1-17.1%; <i>I</i> <sup>2</sup>=0).</p><p><strong>Conclusion: </strong>Endoscopic drainage is safe and effective in children with PFCs. However, future studies are required to compare endoscopic and EUS-guided drainage of PFCs in children.</p>","PeriodicalId":50923,"journal":{"name":"ACM Sigplan Notices","volume":"1 1","pages":"251-262"},"PeriodicalIF":0.0000,"publicationDate":"2022-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9110851/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"ACM Sigplan Notices","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.5223/pghn.2022.25.3.251","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2022/5/9 0:00:00","PubModel":"Epub","JCR":"Q1","JCRName":"Computer Science","Score":null,"Total":0}
引用次数: 0

Abstract

Purpose: Endoscopic drainage is an established treatment modality for adult patients with pancreatic fluid collections (PFCs). Available data regarding the efficacy and safety of endoscopic drainage in pediatric patients are limited. In this systematic review and meta-analysis, we aimed to analyze the outcomes of endoscopic drainage in children with PFCs.

Methods: A literature search was performed in Embase, PubMed, and Google Scholar for studies on the outcomes of endoscopic drainage with or without endoscopic ultrasonography (EUS) guidance in pediatric patients with PFCs from inception to May 2021. The study's primary objective was clinical success, defined as resolution of PFCs. The secondary outcomes included technical success, adverse events, and recurrence rates.

Results: Fourteen studies (187 children, 70.3% male) were included in this review. The subtypes of fluid collection included pseudocysts (60.3%) and walled-off necrosis (39.7%). The pooled technical success rates in studies where drainage of PFCs were performed with and without EUS guidance were 95.3% (95% confidence interval [CI], 89.6-98%; I 2=0) and 93.9% (95% CI, 82.6-98%; I 2=0), respectively. The pooled clinical success after one and two endoscopic interventions were 88.7% (95% CI, 82.7-92.9%; I 2=0) and 92.3% (95% CI, 87.4-95.4%; I 2=0), respectively. The pooled rate of major adverse events was 6.3% (95% CI, 3.3-11.4%; I 2=0). The pooled rate of recurrent PFCs after endoscopic drainage was 10.4% (95% CI, 6.1-17.1%; I 2=0).

Conclusion: Endoscopic drainage is safe and effective in children with PFCs. However, future studies are required to compare endoscopic and EUS-guided drainage of PFCs in children.

查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
胰液积聚儿童的内镜引流效果:系统回顾与元分析》。
目的:内窥镜引流术是治疗胰腺积液(PFC)成人患者的一种成熟治疗方式。有关内镜引流术在儿童患者中的有效性和安全性的现有数据非常有限。在这篇系统综述和荟萃分析中,我们旨在分析内镜引流术在儿童胰腺积液患者中的疗效:方法:我们在 Embase、PubMed 和 Google Scholar 上检索了从开始到 2021 年 5 月期间有关在内镜超声波(EUS)引导下或不在内镜超声波(EUS)引导下对 PFCs 儿童患者进行内镜引流的结果的文献。研究的首要目标是临床成功,即 PFCs 的消退。次要结果包括技术成功率、不良事件和复发率:本次研究共纳入 14 项研究(187 名儿童,70.3% 为男性)。积液的亚型包括假性囊肿(60.3%)和贴壁坏死(39.7%)。在 EUS 引导和无 EUS 引导的情况下进行 PFCs 引流的研究中,汇总的技术成功率分别为 95.3%(95% 置信区间 [CI],89.6-98%;I 2=0)和 93.9%(95% 置信区间,82.6-98%;I 2=0)。经过一次和两次内镜干预后,汇总的临床成功率分别为88.7%(95% CI,82.7-92.9%;I 2=0)和92.3%(95% CI,87.4-95.4%;I 2=0)。主要不良事件的汇总发生率为 6.3% (95% CI, 3.3-11.4%; I 2=0)。内镜引流术后PFCs复发的汇总率为10.4% (95% CI, 6.1-17.1%; I 2=0):结论:内镜下引流术对PFCs患儿安全有效。结论:内镜引流对儿童 PFCs 患者安全有效,但还需在今后的研究中对内镜和 EUS 引导下的儿童 PFCs 引流进行比较。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 去求助
来源期刊
ACM Sigplan Notices
ACM Sigplan Notices 工程技术-计算机:软件工程
CiteScore
4.90
自引率
0.00%
发文量
0
审稿时长
2-4 weeks
期刊介绍: The ACM Special Interest Group on Programming Languages explores programming language concepts and tools, focusing on design, implementation, practice, and theory. Its members are programming language developers, educators, implementers, researchers, theoreticians, and users. SIGPLAN sponsors several major annual conferences, including the Symposium on Principles of Programming Languages (POPL), the Symposium on Principles and Practice of Parallel Programming (PPoPP), the Conference on Programming Language Design and Implementation (PLDI), the International Conference on Functional Programming (ICFP), the International Conference on Object-Oriented Programming, Systems, Languages, and Applications (OOPSLA), as well as more than a dozen other events of either smaller size or in-cooperation with other SIGs. The monthly "ACM SIGPLAN Notices" publishes proceedings of selected sponsored events and an annual report on SIGPLAN activities. Members receive discounts on conference registrations and free access to ACM SIGPLAN publications in the ACM Digital Library. SIGPLAN recognizes significant research and service contributions of individuals with a variety of awards, supports current members through the Professional Activities Committee, and encourages future programming language enthusiasts with frequent Programming Languages Mentoring Workshops (PLMW).
期刊最新文献
Outcomes of Endoscopic Drainage in Children with Pancreatic Fluid Collections: A Systematic Review and Meta-Analysis. Letter from the Chair SEIS Proceedings of the 2018 ACM SIGPLAN International Symposium on Memory Management, ISMM 2018, Philadelphia, PA, USA, June 18, 2018 Proceedings of the 19th ACM SIGPLAN/SIGBED International Conference on Languages, Compilers, and Tools for Embedded Systems, LCTES 2018, Philadelphia, PA, USA, June 19-20, 2018
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1