Antipyretic Activity of Aqueous Extract of Daniellia oliveri Leaves (Rolfe, Hutch Et Dalz) (Fabaceae)

Abstract

The pharmacological study of the aqueous extract of Daniellia oliveri (Fabaceae) leaves revealed antipyretic properties .This dose-dependent reduction in brewer's yeast-induced hyperthermia in rats is similar to that of lysine acetylsalicylate. Qualitative phytochemical screening shows that the aqueous leaf extract of Daniellia oliveri contains polyphenols, flavonoids, saponosides, quinone substances, alkaloids, catechic and gallic tannins, sterols, polyterpenes and cardiodic heterosides. The oral LD50 of the aqueous extract of Daniellia oliveri leaves conducted according to OECD guideline 423 [1], is greater than 5000 mg/kg B.W, making this plant a substance of low toxicity, thus justifying its traditional use in painful ailments.