Genetic Differences Between Endotoxin-Sensitive and Resistant C3H Mice

Zeitschrift für Immunitaetsforschung, Experimentelle und Klinische Immunologie Pub Date : 1976-08-01 DOI:10.1016/S0340-904X(76)80026-7

L.G. Gurtler , W.R. Rank

{"title":"Genetic Differences Between Endotoxin-Sensitive and Resistant C3H Mice","authors":"L.G. Gurtler , W.R. Rank","doi":"10.1016/S0340-904X(76)80026-7","DOIUrl":null,"url":null,"abstract":"<div><p>The 2 related mouse strains C3H/HeJ and C3H/Han differ in their response to endotoxin. C3H/HeJ mice are endotoxin-resistant, C3H/Han mice are - like all other mice - endotoxin-sensitive. The uptake of fluorescent intraperitoneally injected lipopolysaccharide was similar in both mouse strains. The intraperitoneal injection of lipopolysaccharide produced a higher mobilization of neutrophil granulocytes in resistant C3H/HeJ mice than in C3H/Han mice. An opposite pattern of mobilization of neutrophil granulocytes could be observed after injection of the prostaglandins E 1, E 2, and F 1 α; when both mouse strains were compared, a normal mobilization was observed in C3H/Han mice C3H/HeJ mice showed a markedly decreased mobilization.</p><p>If the difference between the 2 strains resides in a single gene locus it is to be assumed that lipopolysaccharide resistance is controlled by the same gene which also effects an impaired response to neutrophil mobilization after prostaglandin application.</p></div>","PeriodicalId":101289,"journal":{"name":"Zeitschrift für Immunitaetsforschung, Experimentelle und Klinische Immunologie","volume":"151 5","pages":"Pages 420-429"},"PeriodicalIF":0.0000,"publicationDate":"1976-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0340-904X(76)80026-7","citationCount":"3","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Zeitschrift für Immunitaetsforschung, Experimentelle und Klinische Immunologie","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0340904X76800267","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}

引用次数: 3

Abstract

The 2 related mouse strains C3H/HeJ and C3H/Han differ in their response to endotoxin. C3H/HeJ mice are endotoxin-resistant, C3H/Han mice are - like all other mice - endotoxin-sensitive. The uptake of fluorescent intraperitoneally injected lipopolysaccharide was similar in both mouse strains. The intraperitoneal injection of lipopolysaccharide produced a higher mobilization of neutrophil granulocytes in resistant C3H/HeJ mice than in C3H/Han mice. An opposite pattern of mobilization of neutrophil granulocytes could be observed after injection of the prostaglandins E 1, E 2, and F 1 α; when both mouse strains were compared, a normal mobilization was observed in C3H/Han mice C3H/HeJ mice showed a markedly decreased mobilization.

If the difference between the 2 strains resides in a single gene locus it is to be assumed that lipopolysaccharide resistance is controlled by the same gene which also effects an impaired response to neutrophil mobilization after prostaglandin application.

查看原文

微信好友朋友圈 QQ好友复制链接

本刊更多论文

内毒素敏感和耐药C3H小鼠的遗传差异

C3H/HeJ和C3H/Han对内毒素的反应不同。C3H/HeJ小鼠具有内毒素抗性，而C3H/Han小鼠像所有其他小鼠一样具有内毒素敏感性。两种小鼠对荧光腹腔注射脂多糖的摄取相似。腹腔注射脂多糖可使耐药C3H/HeJ小鼠比C3H/Han小鼠动员更多的中性粒细胞。注射前列腺素e1、e2和f1 α后，中性粒细胞的动员模式相反;对比两种小鼠品系，C3H/Han小鼠的动员正常，C3H/HeJ小鼠的动员明显降低。如果两个菌株之间的差异存在于单个基因位点，则可以假设脂多糖抗性是由同一基因控制的，该基因也影响前列腺素应用后中性粒细胞动员的受损反应。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文去求助