Effect of the anodal transcranial direct current electrical stimulation on cognition of medical residents with acute sleep deprivation.

IF 2.2 3区文学 0 LANGUAGE & LINGUISTICS Metaphor and Symbol Pub Date : 2022-01-01 DOI:10.5935/1984-0063.20220007

Daniel San-Juan, Raúl Nathanael May Mas, Cuauhtémoc Gutiérrez, Jorge Morales, Ana Díaz, Gerardo Quiñones, Axel Kevin Galindo, Luis Armando Baigts, Cecilia Ximenez-Camilli, David Anschel

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Abstract

Background: Medical residents must sustain acute sleep deprivation, which can lead to nonfatal and fatal consequences in hospitals due to cognitive decline. Anodal transcranial direct current stimulation (a-tDCS) is a safe noninvasive neuromodulation technique that can induce depolarization of neurons. Previous studies in pilots have shown benefits against fatigue increasing wakefulness and cognitive performance. However, the effects of a-tDCS on cognition in acute sleep deprived healthcare workers remains unknown.

Purpose: To evaluate cognitive changes in sleep deprived medical residents after one session of a-tDCS.

Methods: Open clinical test-re-test study including 13 medical residents with acute sleep deprivation. Subjects received 1 session of bifrontal a-tDCS (2mAx20min), anodal over the left dorsolateral prefrontal region. Pre-and-post treatment subjects were tested with Beck anxiety inventory, Beck depression and HVLT tests, Rey´s and Taylor´s figures, Trail Making A/B, Stroop, Aleatory Digit retention test (WAIS), Digits and symbols and MoCA tests. Post-intervention was added the Executive functions and Frontal Lobes Neuropsychological Battery (BANFE2) test and changing the Taylor figure for Reyfigure.

Results: Twelve medical residents were analyzed; 8 men and 4 women, 29.5 (+/-2.2) years mean age. All had a mean of 21.6 (+/-1.3) hours of sleep deprivation. There were no serious adverse events. We found statistically significant difference in Rey´s/Taylor´s figures (p=0.002), Trail Making Test (p=0.005), WAIS IV symbols (p=0.003), Word Stroop (p=0.021). BANFE-2 showed that the main affected area was the orbito-medial prefrontal region.

Conclusion: a-tDCS appears safe and improves working memory, attention, response time and distractors elimination in acute sleep deprived medical residents.

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阳极经颅直流电刺激对急性睡眠不足的医学住院医师认知能力的影响。

背景：医学住院医师必须承受急性睡眠不足，这可能会导致认知能力下降，从而在医院造成非致命性或致命性后果。阳极经颅直流电刺激（a-tDCS）是一种安全的非侵入性神经调节技术，可诱导神经元去极化。之前在飞行员身上进行的研究表明，该技术能有效缓解疲劳，提高清醒度和认知能力。然而，a-tDCS 对急性睡眠不足的医护人员认知能力的影响仍然未知。目的：评估睡眠不足的住院医师在接受一次 a-tDCS 治疗后的认知能力变化：方法：开放式临床测试-再测试研究，包括 13 名急性睡眠不足的住院医师。受试者接受一个疗程的双额叶 a-tDCS 治疗（2mAx20 分钟），在左侧背外侧前额叶区域进行阳极治疗。治疗前后，受试者接受了贝克焦虑量表、贝克抑郁和HVLT测试、雷氏和泰勒数字、A/B寻迹、斯特罗普、Aleatory Digit retention test (WAIS)、Digits and symbols和MoCA测试。干预后增加了执行功能和额叶神经心理测试（BANFE2），并将泰勒图形改为雷弗图形：分析了 12 名医学住院医师，其中男性 8 人，女性 4 人，平均年龄 29.5 (+/-2.2) 岁。他们的平均睡眠时间为 21.6 (+/-1.3) 小时。没有发生严重不良事件。我们发现，Rey´s/Taylor´s数字（p=0.002）、Trail Making Test（p=0.005）、WAIS IV符号（p=0.003）和Word Stroop（p=0.021）的差异具有统计学意义。BANFE-2显示，受影响的主要区域是眶内侧前额叶区域。结论：a-tDCS似乎是安全的，它能改善急性睡眠不足的医学住院医师的工作记忆、注意力、反应时间和分心消除能力。

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Metaphor and Symbol Multiple-

CiteScore

2.90

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0.00%

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期刊介绍： Metaphor and Symbol: A Quarterly Journal is an innovative, multidisciplinary journal dedicated to the study of metaphor and other figurative devices in language (e.g., metonymy, irony) and other expressive forms (e.g., gesture and bodily actions, artworks, music, multimodal media). The journal is interested in original, empirical, and theoretical research that incorporates psychological experimental studies, linguistic and corpus linguistic studies, cross-cultural/linguistic comparisons, computational modeling, philosophical analyzes, and literary/artistic interpretations. A common theme connecting published work in the journal is the examination of the interface of figurative language and expression with cognitive, bodily, and cultural experience; hence, the journal''s international editorial board is composed of scholars and experts in the fields of psychology, linguistics, philosophy, computer science, literature, and media studies.