Parathyroid Hormone Abnormalities Related with Mitral and Aortic Valve Calcification in Maintenance Hemodialysis Patients

Abstract

Back ground: parathyroid hormone abnormalities and minerals disorder are common in hemodialysis patients which increase mitral and aortic valve calcification as well as mortality and morbidity. The aim of the study: to verify the risk factors associated with valvular calcification and a benefit of Kidney Disease Improving Global Outcome guidelines foe minerals level. Patients and Methods: observation study of (52) hemodialysis patients divided into two groups (C) and (D) depend on the presence and absence of valve calcification by echocardiography then compared according to their association with risk factors and achievement of global guideline. Results: group (C) 14 patients, group (D) 38, by comparison the age was a strong risk factor mean age for (C) = 58.71 ± (12.70) vs 44.39 ± (16.57) for (D) p- value = 0.005, for other risk factors, group (C) had longer duration of dialysis, higher use of drugs that increase calcium load, higher in hyperphosphatemia, hypercalcemia and a dynamic bone disease although the difference statistically not significant. Discussion: all factors that mentioned were a risk factors for valvular calcification and global guidelines for minerals level were beneficial. Conclusion: we should know these risk factors because many of them are treatable. Key words: PTH (parathyroid hormone), ca (calcium), po4 (phosphate), HTN (hypertension), DM (diabetes) and ESRD (end stage renal disease).