Modern diagnostics in IgE-mediated cow’s milk allergy

Abstract

Cow's milk allergy (CMA) is the most common food allergy in infants and young children. Allergic reactions can vary from mild to severe, like an anaphylactic shock. In case of CMA diagnosis suspicion skin prick tests (SPT), immunoassays of specific IgE (sIgE) in blood serum (in vitro tests) and oral food challenge (OFC) tests can be performed.  SPT wheal diameter and the level of serum specific IgE to milk do not correlate with severity of clinical symptoms, while procedure of OFC is often difficult or even imposible in practice. Therefore component resolved-diagnostics (CRD) tests are a new diagnostic tool, which allows for a better correlation of laboratory test results with the observed clinical symptoms and indicate the triggering allergens.