Screening of Anticancer Potential and DNA Damage Ability of Syringodium isoetifolium against HeLa Cell Line

Abstract

Cervical cancer is a kind of cancer, which mainly occurs in the lower portion of uterus. Human papilloma virus plays a major role in the occurrence of cervical cancer. Major symptoms are vaginal bleeding, foul odour in vagina, pelvic pain, etc. It is mostly diagnosed by biopsy. Chemotherapy, radiation and surgery are the widely used treatments for cervical cancer, but the main drawback was their side effects. To avoid these conditions people might follow the ancient methods of treatment. Medicinal plants got wide attention in the current society to cure various diseases. The seagrass obtained from the seashores possess a wide range of medicinal properties like anticancer activity. In this study, the anticancer potentials of the seagrass, Syringodium isoetifolium was checked with the help of MTT and Comet assays. The various functional compounds present in the seagrass were also detected by FT-IR analysis. From the results obtained from MTT assay, the least inhibitory concentration of the sample was found to be 35.63 μg/mL. Further results obtained from the Comet assay prove that the sample has the ability to kill the cancer cells. This study concludes that the methanolic extract of Syringodium isoetifolium can be used as an alternative and marine based source for the treatment of cervical cancer.