Stress-Induced Hyperthermia, the Serotonin System and Anxiety

C. Vinkers, B. Olivier, J. Bouwknecht, L. Groenink, J. Olivier
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引用次数: 8

Abstract

The serotonin (5-HT) system plays a key role in the pathophysiology of psychiatric disorders including mood and anxiety disorders. A role for serotonin in stress-related disorders is further supported by the fact that clinically effective treatments for these disorders alter serotonergic neurotransmission. The therapeutic potential of serotonergic pharmacological interventions has resulted in a variety of preclinical approaches to study the serotonin system. Of these, the stress-induced hyperthermia (SIH) paradigm has been extensively used to study the serotonin system at a preclinical level. The SIH response uses the transient rise in body temperature in response to a stressor which can be reduced using anxiolytic drugs including benzodiazepines, CRF receptor antagonists and serotonergic ligands. The present review aims to discuss the acute and chronic effects of 5-HT ligands on the SIH response. Also, the SIH response in genetically modified mice that lack or overexpress specific serotonergic receptor subtypes or the serotonin transporter will be summarized. 5-HT1A receptor ligands reduce the SIH response, whereas acute administration of other serotonergic drugs (including 5-HT1B, 5-HT2 and 5-HT3 modulators and SSRIs) generally does not influence the SIH response. Also, the SIH paradigm is generally insensitive to detect the anxiolytic effects of chronic serotonergic antidepressants in rodents, and serotonergic drugs that have been found to reduce the SIH response acutely do so irrespective of the healthy or pathological status of an individual.
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应激性热疗,血清素系统和焦虑
5-羟色胺(5-HT)系统在包括情绪和焦虑障碍在内的精神疾病的病理生理学中起着关键作用。5 -羟色胺在压力相关疾病中的作用进一步得到了临床有效治疗这些疾病改变5 -羟色胺能神经传递这一事实的支持。5 -羟色胺能药物干预的治疗潜力导致了各种临床前方法来研究5 -羟色胺系统。其中,应激性热疗(SIH)模式已被广泛用于临床前水平的血清素系统研究。SIH反应利用体温的短暂上升来应对压力源,可以使用抗焦虑药物,包括苯二氮卓类药物、CRF受体拮抗剂和5 -羟色胺能配体来降低压力源。本综述旨在讨论5-羟色胺配体对SIH反应的急性和慢性影响。此外,将总结缺乏或过度表达特定血清素能受体亚型或血清素转运体的转基因小鼠的SIH反应。5-HT1A受体配体可降低SIH反应,而其他5-羟色胺能药物(包括5-HT1B、5-HT2和5-HT3调节剂和SSRIs)的急性给药通常不会影响SIH反应。此外,SIH模式通常对检测啮齿动物慢性5 -羟色胺能抗抑郁药的焦虑作用不敏感,并且已经发现5 -羟色胺能药物可以急剧降低SIH反应,而不管个体的健康或病理状态如何。
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