DC operated atmospheric pressure air plasma jet for biomedical applications

J. Kolb, R. O. Price, M. Stacey, R. J. Swanson, A. Bowman, R. Chiavarini, K. Schoenbach
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Abstract

We have previously presented a gas discharge assembly based on a microhollow cathode geometry which can be operated with a dc current at atmospheric pressure with ambient air1. By flowing air through the discharge channel at a rate of about 7 Ltr/min a 10-20-mm long plume is observed. The temperature in this expelled afterglow plasma reaches values that are close to room temperature at a distance of 5 mm from the discharge origin. Emission spectra show that atomic oxygen, hydroxyl ions and various nitrogen compounds are generated in the discharge and are driven out with the gas flow. The most prominent secondary discharge product, ozone, is detected in high concentrations. The low heavy-particle temperature allows us to use this exhaust stream on biological samples and tissues without thermal damage. The high levels of reactive species suggest an effective treatment for pathological skin conditions caused, in particular, by infectious agents. In the first experiments, we have successfully tested the efficacy of this afterglow plasma on Candida kefyr (a yeast), E.coli (bacteria), and a matching E.coli strain-specific virus, 0X174 (a bacteriophage). All pathogens investigated responded well to the treatment. In the yeast case, complete eradication of the organism in the treated area could be achieved with an exposure of 90 seconds at a distance of 5 mm. A 10-fold increase of exposure, to 900 seconds caused no observable damage to murine integument. The quantification of the response, and studies of possible mechanisms are underway.
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用于生物医学应用的直流操作大气压空气等离子体射流
我们之前已经提出了一种基于微空心阴极几何结构的气体放电组件,该组件可以在大气压下与环境空气一起使用直流电流进行操作。当空气以约7升/分钟的速度流过排出通道时,可以观察到10-20毫米长的羽流。在距离放电源5毫米的地方,被排出的余辉等离子体的温度达到接近室温的值。发射光谱显示,在放电过程中产生原子氧、羟基离子和各种氮化合物,并随气流排出。最突出的二次排放产物,臭氧,被检测到高浓度。低重粒子温度使我们能够在生物样本和组织上使用这种废气流而不会产生热损伤。高水平的反应性物质表明对病理性皮肤状况的有效治疗,特别是由传染性病原体引起的。在第一个实验中,我们成功地测试了这种余辉等离子体对念珠菌kefyr(一种酵母)、大肠杆菌(一种细菌)和与之匹配的大肠杆菌菌株特异性病毒0X174(一种噬菌体)的功效。所有调查的病原体对治疗反应良好。在酵母菌的情况下,在5毫米的距离上暴露90秒即可实现处理区域内生物体的完全根除。暴露量增加10倍至900秒,对小鼠的皮肤没有明显的损伤。反应的量化和可能机制的研究正在进行中。
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