Ring Opening of Epoxides and Aziridines with Benzotriazoles Using Magnetically Retrievable Graphene Based (CoFe@rGO) Nanohybrid

Abstract

Reduced Graphene oxide (rGO) behaves as an excellent heterogeneous catalyst because of its remarkable characteristics such as large specific surface area and high thermal stability. In this regards, Graphene oxide was converted to magnetic nanohybrid (CoFe@rGO) and utilized as an efficient heterogeneous catalyst for the ring opening reactions and act as Lewis acid to promote the reaction. Developed a new facile, environmentally benign and green methodology for the synthesis of β-hydroxytriazoles and β- N -tosylsulfonamidetriazoles derivatives via ring opening reaction of epoxides and aziridines respectively in the presence of CoFe@rGO nanohybrid as catalyst in good to excellent yields under solvent free reaction conditions. Catalyst was separated from the reaction mixture by an external magnet, recycled and reused up to six catalytic runs without significant loss of catalytic activity. Environmentally benign conditions, cheap starting materials, shorter reaction times, easy work-up and purification of the products, high regioselectivity, high yields, recyclability and reusability of catalyst are the main advantages of our protocol.