Kinetic and Mechanistic Studies of Substitution on [(H2O)(tap)2RuORu(tap)2(H2O)]2+ Ion with Uridine in Aqueous Medium

Abstract

*Corresponding author: e-mail: alakghosh2002@yahoo.co.in Platinum complexes of ruthenium, rhodium, iridium and palladium have been reported to have considerable antibacterial power [1,2]. Ruthenium complexes are an order of magnitude less toxic than cis-platin. Studies demonstrate that a number of ruthenium compounds serve as bacterial mutagens and so indicate that at least some ruthenium complexes are capable of damaging genetic material. Screening studies on a series of ruthenium complexes show that many of them do exhibit antitumor [3-6], antiherpes [7], anti-HIV [8], antiamebic [9], anticancer [10], antileucomic [11] and antifungal activity [12,13]. Ruthenium-arene organometallic compounds are postulated to interact with DNA targets, although protein interactions have also been shown. These organometallic species are more stable than inorganic metal compounds, which facilitate pharmacokinetic studies, thereby increasing the Inorganic Reaction Mechanisims, Vol. 6, pp. 9-17 © 2006 Old City Publishing, Inc. Reprints available directly from the publisher Published by license under the OCP Science imprint, Photocopying permitted by license only a member of the Old City Publishing Group.