PHYTOCHEMISTRY PROFILE, EFFICACY, AND SAFETY OF GREEN TEA (Camellia sinensis (L.) Kuntze) FOR BREAST CANCER CHEMOPREVENTION: A SYSTEMATIC REVIEW

Jurnal Tumbuhan Obat Indonesia Pub Date : 2021-12-01 DOI:10.22435/jtoi.v14i2.4994

D. Hartanti, Siti Rofida

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Abstract

ABSTRACT The consumption of tea (Camellia sinensis (L.) Kuntze), mainly green tea, is famous for various health benefits. This review summarizes the potential use of green tea and epigallocatechin gallate (EGCG) for breast cancer chemoprevention. The data were retrieved from the online publication on the Pubmed database and covered the phytochemistry, preclinical study, and clinical trial of green tea related to its use as a breast cancer chemopreventive agent. Catechins, particularly EGCG, are the chemopreventive bioactive constituents of green tea. Preclinical studies demonstrated that the anti-proliferative and induction of apoptosis potentials of green tea are mediated through several different mechanisms. However, no association between green tea intake and a lowered breast cancer risk in human studies, but it might be favorable for secondary cancer prevention. Keywords: green tea, epigallocatechin gallate, chemopreventive, breast cancer. ABSTRAK Konsumsi teh (Camellia sinensis (L.) Kuntze), terutama teh hijau, terkenal dengan berbagai manfaat kesehatannya. Ulasan ini merangkum potensi penggunaan teh hijau dan epigallocatechin gallate (EGCG) untuk kemoprevensi kanker payudara. Data diambil dari publikasi online di database Pubmed dan mencakup fitokimia, studi praklinis, dan uji klinis teh hijau terkait dengan penggunaannya sebagai agen kemopreventif kanker payudara. Katekin, terutama EGCG, adalah konstituen bioaktif kemopreventif teh hijau. Studi praklinis menunjukkan bahwa anti-proliferatif dan induksi potensi apoptosis teh hijau dimediasi melalui beberapa mekanisme yang berbeda. Namun, tidak ada hubungan antara asupan teh hijau dan penurunan risiko kanker payudara dalam penelitian pada manusia, tetapi mungkin menguntungkan untuk pencegahan kanker sekunder. Kata kunci: teh hijau, epigallocatechin gallate, kemopreventif, kanker payudara.

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绿茶(Camellia sinensis (L.))的植物化学特征、功效和安全性乳腺癌化学预防:一项系统综述

茶(Camellia sinensis (L.))的消费(Kuntze)，主要是绿茶，以各种健康益处而闻名。本文综述了绿茶和表没食子儿茶素没食子酸酯(EGCG)在乳腺癌化学预防中的潜在用途。这些数据是从Pubmed数据库的在线出版物中检索的，涵盖了绿茶作为乳腺癌化学预防剂的植物化学、临床前研究和临床试验。儿茶素，尤其是EGCG，是绿茶中的化学预防生物活性成分。临床前研究表明，绿茶的抗细胞增殖和诱导细胞凋亡可能通过多种不同的机制介导。然而，在人体研究中，绿茶摄入量与降低乳腺癌风险之间没有联系，但它可能有利于继发性癌症的预防。关键词:绿茶，表没食子儿茶素没食子酸酯，化学预防，乳腺癌【摘要】茶花(Camellia sinensis)Kuntze)， terutama teh hijau, terkenal dengan berbagai manfaat kesehatannya。乌拉山尼梅兰库木潜能，penggunaan的hijau和表没食子儿茶素没食子酸酯(EGCG)，以kemopreveni kanker payudara。数据来源:Pubmed . Pubmed . Pubmed . Pubmed . Pubmed . Pubmed . Pubmed . Pubmed . Pubmed . Pubmed . Pubmed . Pubmed . Pubmed . Pubmed . Pubmed . Pubmed . Pubmed . Pubmed . Pubmed . Pubmed . Pubmed . Pubmed . Pubmed . Pubmed . Pubmed . Pubmed。Katekin, terutama EGCG, adalah konstitute, bioaktif kemi预防hijau。白眉草抗增殖和细胞潜在凋亡的研究及其与细胞凋亡机制的关系。Namun,有些ada hubungan安塔拉asupan格兰hijau丹penurunan risiko kanker payudara dalam penelitian篇manusia, tetapi mungkin menguntungkan为她pencegahan kanker sekunder。没食子儿茶素没食子酸酯，kemprevent, kanker payudara。

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Jurnal Tumbuhan Obat Indonesia

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